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In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem
http://hdl.handle.net/10091/17657
http://hdl.handle.net/10091/17657b0340f37-8584-4d9d-a0d9-2852d98d5bbb
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sugiyama, Daisuke
× Sugiyama, Daisuke× Hur, Sung Won× Pickering, Anthony E.× Kase, Daisuke× Kim, Sang Jeong× Kawamata, Mikito× Imoto, Keiji× Furue, Hidemasa |
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出版者 | ||||||
出版者 | WILEY-BLACKWELL | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF PHYSIOLOGY-LONDON. 590(10):2225-2231 (2012) | |||||
書誌情報 |
JOURNAL OF PHYSIOLOGY-LONDON 巻 590, 号 10, p. 2225-2231, 発行日 2012-05 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第940号)・杉山 大介 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ‘The definitive version is available at www.blackwell-synergy.com’ and www.jphysiol.org . | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Locus coeruleus (LC) neurones extend noradrenergic projections throughout the neuroaxis and are involved in homeostatic functions such as pain modulation, arousal and cardio-respiratory control. To address the cellular mechanisms underlying pain modulation we have developed a patch-clamp recording technique from LC neurones in anaesthetized rats. These recordings showed LC discharge in vivo to be driven by both spontaneous membrane potential oscillations and CNQX-sensitive EPSCs opposed by bicuculine-sensitive IPSCs. Hindlimb pinch evoked a biphasic action potential response underpinned by a slow monophasic excitatory current. This approach allows detailed characterisation of the synaptic and integrative mechanisms of LC responses to naturalistic stimulation. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1113/jphysiol.2011.226407 | |||||
関連名称 | 10.1113/jphysiol.2011.226407 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |