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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem

http://hdl.handle.net/10091/17657
http://hdl.handle.net/10091/17657
b0340f37-8584-4d9d-a0d9-2852d98d5bbb
名前 / ファイル ライセンス アクション
H24Kou940_Sugiyama.pdf H24Kou940_Sugiyama.pdf (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-27
タイトル
言語 en
タイトル In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sugiyama, Daisuke

× Sugiyama, Daisuke

WEKO 17392

Sugiyama, Daisuke

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Hur, Sung Won

× Hur, Sung Won

WEKO 17393

Hur, Sung Won

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Pickering, Anthony E.

× Pickering, Anthony E.

WEKO 17394

Pickering, Anthony E.

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Kase, Daisuke

× Kase, Daisuke

WEKO 17395

Kase, Daisuke

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Kim, Sang Jeong

× Kim, Sang Jeong

WEKO 17396

Kim, Sang Jeong

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Kawamata, Mikito

× Kawamata, Mikito

WEKO 17397

Kawamata, Mikito

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Imoto, Keiji

× Imoto, Keiji

WEKO 17398

Imoto, Keiji

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Furue, Hidemasa

× Furue, Hidemasa

WEKO 17399

Furue, Hidemasa

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出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 JOURNAL OF PHYSIOLOGY-LONDON. 590(10):2225-2231 (2012)
書誌情報 JOURNAL OF PHYSIOLOGY-LONDON

巻 590, 号 10, p. 2225-2231, 発行日 2012-05
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第940号)・杉山 大介
内容記述
内容記述タイプ Other
内容記述 ‘The definitive version is available at www.blackwell-synergy.com’ and www.jphysiol.org .
抄録
内容記述タイプ Abstract
内容記述 Locus coeruleus (LC) neurones extend noradrenergic projections throughout the neuroaxis and are involved in homeostatic functions such as pain modulation, arousal and cardio-respiratory control. To address the cellular mechanisms underlying pain modulation we have developed a patch-clamp recording technique from LC neurones in anaesthetized rats. These recordings showed LC discharge in vivo to be driven by both spontaneous membrane potential oscillations and CNQX-sensitive EPSCs opposed by bicuculine-sensitive IPSCs. Hindlimb pinch evoked a biphasic action potential response underpinned by a slow monophasic excitatory current. This approach allows detailed characterisation of the synaptic and integrative mechanisms of LC responses to naturalistic stimulation.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1113/jphysiol.2011.226407
関連名称 10.1113/jphysiol.2011.226407
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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