@article{oai:soar-ir.repo.nii.ac.jp:00007187,
 author = {Sugiyama,  Daisuke and Hur,  Sung Won and Pickering,  Anthony E. and Kase,  Daisuke and Kim,  Sang Jeong and Kawamata,  Mikito and Imoto,  Keiji and Furue,  Hidemasa},
 issue = {10},
 journal = {JOURNAL OF PHYSIOLOGY-LONDON},
 month = {May},
 note = {信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第940号）・杉山 大介, ‘The definitive version is available at www.blackwell-synergy.com’ and www.jphysiol.org ., Locus coeruleus (LC) neurones extend noradrenergic projections throughout the neuroaxis and are involved in homeostatic functions such as pain modulation, arousal and cardio-respiratory control. To address the cellular mechanisms underlying pain modulation we have developed a patch-clamp recording technique from LC neurones in anaesthetized rats. These recordings showed LC discharge in vivo to be driven by both spontaneous membrane potential oscillations and CNQX-sensitive EPSCs opposed by bicuculine-sensitive IPSCs. Hindlimb pinch evoked a biphasic action potential response underpinned by a slow monophasic excitatory current. This approach allows detailed characterisation of the synaptic and integrative mechanisms of LC responses to naturalistic stimulation., Article, JOURNAL OF PHYSIOLOGY-LONDON. 590(10):2225-2231 (2012)},
 pages = {2225--2231},
 title = {In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem},
 volume = {590},
 year = {2012}
}