@article{oai:soar-ir.repo.nii.ac.jp:00007194,
 author = {Yoshizawa,  Katsumi and Nakajima,  Shinsuke and Notake,  Tsuyoshi and Miyagawa,  Shin-Ichi and Hida,  Shigeaki and Taki,  Shinsuke},
 issue = {10},
 journal = {JOURNAL OF IMMUNOLOGY},
 month = {Nov},
 note = {信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第910号）・好沢克, Originally published in The Journal of Immunology. Yoshizawa, K; Nakajima, S; Notake, T; Miyagawa, SI; Hida, S; Taki, S. 2011. IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice . J. Immunol. Vol.187(10): pp5162-pp5169. Copyright (C) 2011 The American Association of Immunologists, Inc., In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15-high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15(-/-) than from control donor cells in radiation BM chimeras, and the rate of IL-15-induced cell division in vitro was higher in NK cells in the spleen and BM from IL-5(-/-) mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15-induced proliferation was most prominent in CD11b(-)DX5(hi) cells. Notably, IL-15-mediated preferential expansion (but not conversion from Ly49(-) cells) of Ly49(+) NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15-driven extramarrow expansion under steady-state or inflammatory conditions. The Journal of Immunology, 2011, 187: 5162-5169., Article, JOURNAL OF IMMUNOLOGY. 187(10):5162-5169 (2011)},
 pages = {5162--5169},
 title = {IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice},
 volume = {187},
 year = {2011}
}