{"created":"2021-03-01T06:11:02.575806+00:00","id":7194,"links":{},"metadata":{"_buckets":{"deposit":"bbba8f81-b7d1-438a-91c8-55870ade0751"},"_deposit":{"id":"7194","owners":[],"pid":{"revision_id":0,"type":"depid","value":"7194"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00007194","sets":["461:848:849"]},"author_link":["17456","17457","17458","17459","17460","17461"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"5169","bibliographicPageStart":"5162","bibliographicVolumeNumber":"187","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF IMMUNOLOGY"}]}]},"item_6_description_19":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第910号）・好沢克","subitem_description_type":"Other"},{"subitem_description":"Originally published in The Journal of Immunology. Yoshizawa, K; Nakajima, S; Notake, T; Miyagawa, SI; Hida, S; Taki, S. 2011. IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice . J. Immunol. Vol.187(10): pp5162-pp5169. Copyright (C) 2011 The American Association of Immunologists, Inc.","subitem_description_type":"Other"}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15-high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15(-/-) than from control donor cells in radiation BM chimeras, and the rate of IL-15-induced cell division in vitro was higher in NK cells in the spleen and BM from IL-5(-/-) mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15-induced proliferation was most prominent in CD11b(-)DX5(hi) cells. Notably, IL-15-mediated preferential expansion (but not conversion from Ly49(-) cells) of Ly49(+) NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15-driven extramarrow expansion under steady-state or inflammatory conditions. The Journal of Immunology, 2011, 187: 5162-5169.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JOURNAL OF IMMUNOLOGY. 187(10):5162-5169 (2011)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Taki, Shinsuke","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296767300025"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"AMER ASSOC IMMUNOLOGISTS"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"21967894"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21967894","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.4049/jimmunol.1101561"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4049/jimmunol.1101561","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (C) 2011 The American Association of Immunologists, Inc."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-1767","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00699656","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshizawa,  Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima,  Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Notake,  Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyagawa,  Shin-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hida,  Shigeaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taki,  Shinsuke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"H23Kou910_Yoshizawa.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H23Kou910_Yoshizawa.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/7194/files/H23Kou910_Yoshizawa.pdf"},"version_id":"554ac04c-15b8-4b73-b730-15917622ccbd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["849"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-10-02"},"publish_date":"2012-10-02","publish_status":"0","recid":"7194","relation_version_is_last":true,"title":["IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:20:10.671638+00:00"}