@article{oai:soar-ir.repo.nii.ac.jp:00007196,
 author = {Hashimoto,  Koji and Kamijo,  Yuji and Nakajima,  Takero and Harada,  Makoto and Higuchi,  Makoto and Ehara,  Takashi and Shigematsu,  Hidekazu and Aoyama,  Toshifumi},
 journal = {PPAR RESEARCH},
 month = {},
 note = {信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第924号）・橋本幸始, The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a member of the steroid/nuclear receptor superfamily, is known to perform various physiological functions. Recently, we reported that PPAR alpha in activated mesangial cells exerted anti-inflammatory effects and that the deficiency of PPAR alpha resulted in high susceptibility to glomerulonephritis. To investigate whether PPAR alpha activation improves the disease activity of MsPGN, we examined the protective effects of a PPAR alpha agonist, clofibrate, in a well-established model of human MsPGN, anti-Thy1 nephritis, for the first time. This study demonstrated that pretreatment with clofibrate (via a 0.02% or 0.1% clofibrate-containing diet) continuously activated the glomerular PPAR alpha, which outweighed the PPAR alpha deterioration associated with the nephritic process. The PPAR alpha activation appeared to suppress the NF-kappa B signaling pathway in glomeruli by the induction of I kappa B alpha, resulting in the reduction of proteinuria and the amelioration of the active inflammatory pathologic glomerular changes. These findings suggest the antinephritic potential of PPAR alpha-related medicines against MsPGN. PPAR alpha-related medicines might be useful as a treatment option for CKD., Article, PPAR Research. Volume 2012 (2012), Article ID 976089, 11 pages},
 title = {PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling},
 year = {2012}
}