{"_buckets": {"deposit": "d84bb920-6296-4e9a-8c3c-82370c4df48e"}, "_deposit": {"id": "7204", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "7204"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00007204"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "2135", "bibliographicPageStart": "2127", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "NEUROCHEMICAL RESEARCH"}]}]}, "item_6_description_19": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u4fe1\u5dde\u5927\u5b66\u535a\u58eb\uff08\u533b\u5b66\uff09\u30fb\u5b66\u4f4d\u8ad6\u6587\u30fb\u5e73\u621023\u5e743\u670831\u65e5\u6388\u4e0e\uff08\u7532\u7b2c890\u53f7\uff09\u30fb\u65e5\u6839\u91ce\u6643\u4ee3", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "NEUROCHEMICAL RESEARCH. 36(11):2127-2135 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Yoshida, Kunihiro", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yhfNHFkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000296523800022"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER/PLENUM PUBLISHERS"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21706374"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=21706374", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s11064-011-0537-8"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1007/s11064-011-0537-8", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0364-3190", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0364-3190", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA0075462X", "subitem_source_identifier_type": "NCID"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "To clarify the neuroprotective property of ceruloplasmin and the pathogenesis of aceruloplasminemia, we generated ceruloplasmin-deficient (CP(-/-)) mice on the C57BL/10 genetic background and further treated them with a mitochondrial complex I inhibitor, rotenone. There was no iron accumulation in the brains of CP(-/-) mice at least up to 60 weeks of age. Without rotenone treatment, CP(-/-) mice showed slight motor dysfunction compared with CP(+/+) mice, but there were no detectable differences in the levels of oxidative stress markers between these two groups. A low dose of rotenone did not affect the mitochondrial complex I activity in our mice, however, it caused a significant change in motor behavior, neuropathology, or the levels of oxidative stress markers in CP(-/-) mice, but not in CP(+/+) mice. Our data support that ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity, probably through its antioxidant properties independently of its function of iron metabolism."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hineno,  Akiyo"}], "nameIdentifiers": [{"nameIdentifier": "17530", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneko,  Kazuma"}], "nameIdentifiers": [{"nameIdentifier": "17531", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida,  Kunihiro"}], "nameIdentifiers": [{"nameIdentifier": "17532", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda,  Shu-ichi"}], "nameIdentifiers": [{"nameIdentifier": "17533", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "H23Kou890_Hineno.pdf", "filesize": [{"value": "3.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3500000.0, "url": {"label": "H23Kou890_Hineno.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/7204/files/H23Kou890_Hineno.pdf"}, "version_id": "a7cd29e7-551c-4962-bed0-3cf12c025157"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Ceruloplasmin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Iron", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rotenone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidative stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Antioxidant", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity"}]}, "item_type_id": "6", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/16019", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2012-10-01"}, "publish_date": "2012-10-01", "publish_status": "0", "recid": "7204", "relation": {}, "relation_version_is_last": true, "title": ["Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity"], "weko_shared_id": null}