@article{oai:soar-ir.repo.nii.ac.jp:00008007,
 author = {Takahashi,  Jun and Kobayashi,  Hirokazu and Wakabayashi,  Shinji and Deguchi,  Masao and Ito,  Hidehiro and Mogami,  Yuji and Tanikawa,  Hirotaka and Nakagawa,  Hiroyuki and Moriya,  Hideki and Ashizawa,  Ryohei and Takahara,  Kenji and Kinoshita,  Hisatoshi and Tateiwa,  Yutaka and Misawa,  Hiromichi and Tsutsumimoto,  Takahiro and Nakakohji,  Taku and Yuzawa,  Yohei and Sawaumi,  Akihito and Hidai,  Yohei and Matsuda,  Satoshi and Nakamura,  Isao and Toba,  Shigeyuki and Kamimura,  Mikio and Nakane,  Takeshi and Hirabayashi,  Hiroki and Hashidate,  Hiroyuki and Ogihara,  Nobuhide and Mukaiyama,  Keijiro and Kato,  Hiroyuki and Ohtsuka,  Kuniyoshi},
 issue = {2},
 journal = {JOURNAL OF ORTHOPAEDIC SCIENCE},
 month = {Mar},
 note = {Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time < 15 min. The mean EQ-5D utility value for QOL was 0.59 +/- A 0.12. This value was significantly associated with maximum walking time (p = 0.030) based on classification of patients into groups with walking times < 7.5, 7.5-15, 15-30, and > 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects., Article, JOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)},
 pages = {208--215},
 title = {The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis},
 volume = {18},
 year = {2013}
}