{"created":"2021-03-01T06:11:52.316127+00:00","id":8018,"links":{},"metadata":{"_buckets":{"deposit":"2380dc48-f8f7-4376-914c-1c0c823917cc"},"_deposit":{"id":"8018","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8018"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00008018","sets":["882:883"]},"author_link":["22035","22036","22037","22038","22039","22040","22041"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2183","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The molecular mechanism of muscle degeneration in a lethal muscle disorder Duchene muscular dystrophy (DMD) has not been fully elucidated. The dystrophic dog, a model of DMD, shows a high mortality rate with a marked increase in serum creatine kinase (CK) levels in the neonatal period. By measuring serum CK levels in cord and venous blood, we found initial pulmonary respiration resulted in massive diaphragm damage in the neonates and thereby lead to the high serum CK levels. Furthermore, molecular biological techniques revealed that osteopontin was prominently upregulated in the dystrophic diaphragm prior to the respiration, and that immediate-early genes (c-fos and egr-1) and inflammation/immune response genes (IL-6, IL-8, COX-2, and selectin E) were distinctly overexpressed after the damage by the respiration. Hence, we segregated dystrophic phases at the molecular level before and after mechanical damage. These molecules could be biomarkers of muscle damage and potential targets in pharmaceutical therapies.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"SCIENTIFIC REPORTS. 3:2183 (2013)","subitem_description_type":"Other"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000321735200002"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"NATURE PUBLISHING GROUP"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"23851606"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/23851606","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/srep02183"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep02183","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura,  Akinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi,  Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuraoka,  Mutsuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuasa,  Katsutoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yugeta,  Naoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada,  Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda,  Shin'ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22041","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Initial_Pulmonary_Respiration_Causes_Massive_Diaphragm.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Initial_Pulmonary_Respiration_Causes_Massive_Diaphragm.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/8018/files/Initial_Pulmonary_Respiration_Causes_Massive_Diaphragm.pdf"},"version_id":"d8f82bba-5165-492e-a75b-3cb755ebe097"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["883"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-20"},"publish_date":"2014-06-20","publish_status":"0","recid":"8018","relation_version_is_last":true,"title":["Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:00:11.438516+00:00"}