{"created":"2021-03-01T06:11:53.077551+00:00","id":8028,"links":{},"metadata":{"_buckets":{"deposit":"2d55ef15-9d08-4b0c-9df4-0660b69e8183"},"_deposit":{"id":"8028","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8028"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00008028","sets":["882:883"]},"author_link":["22116","22117","22118","22119","22120","22121"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"657","bibliographicPageStart":"653","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"DRUG METABOLISM AND PHARMACOKINETICS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human fetal liver (HFL) cells express major drug metabolic enzymes CYP3A4, CYP3A5 and CYP3A7. In the fetal hepatocytes, betamethasone and dexamethasone (DEX) markedly enhanced the expression levels of CYP3A4 and CYP3A7 mRNAs and slightly increased the expression level of CYP3A5 mRNA. Interestingly, a high correlation between the CYP3A induction ability and the intensity of anti-inflammatory effect was observed. Human glucocorticoid receptor (GR) small interfering RNA clearly attenuated the expression level of GR mRNA, and diminished the DEX-stimulated CYP3A4, CYP3A5 and CYP3A7 expression in HFL cells. These findings indicate that GR mediates the induction of CYP3A4 and CYP3A7 expression in human fetal hepatocytes as well as the CYP3A5.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"DRUG METABOLISM AND PHARMACOKINETICS. 27(6):653-657 (2012)","subitem_description_type":"Other"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000312616800011"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"JAPANESE SOC STUDY XENOBIOTICS"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"22673009"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/22673009","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.2133/dmpk.DMPK-12-NT-018"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2133/dmpk.DMPK-12-NT-018","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2012 The Japanese Society for the Study of Xenobiotics"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-4367","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1162652X","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsunaga,  Tamihide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruyama,  Masataka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsubara,  Tsutomu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata,  Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamazoe,  Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohmori,  Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Mechanisms_CYP3A_Induction_Glucocorticoids_Human.pdf","filesize":[{"value":"351.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Mechanisms_CYP3A_Induction_Glucocorticoids_Human.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/8028/files/Mechanisms_CYP3A_Induction_Glucocorticoids_Human.pdf"},"version_id":"018edc4c-4b43-4d02-805d-22c69bc3314d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CYP3A","subitem_subject_scheme":"Other"},{"subitem_subject":"induction","subitem_subject_scheme":"Other"},{"subitem_subject":"glucocorticoid","subitem_subject_scheme":"Other"},{"subitem_subject":"human fetal liver cells","subitem_subject_scheme":"Other"},{"subitem_subject":"glucocorticoid receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"small interfering RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"specific small interfering RNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["883"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-20"},"publish_date":"2014-06-20","publish_status":"0","recid":"8028","relation_version_is_last":true,"title":["Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:26:00.377134+00:00"}