@article{oai:soar-ir.repo.nii.ac.jp:00008044,
 author = {Tomita,  Takeshi and Hata,  Takeki and Takeuchi,  Takahiro and Oguchi,  Yasutaka and Okada,  Ayako and Aizawa,  Kazunori and Koshikawa,  Megumi and Otagiri,  Kyuhachi and Motoki,  Hirohiko and Kasai,  Hiroki and Izawa,  Atsushi and Koyama,  Jun and Hongo,  Minoru and Ikeda,  Uichi},
 issue = {4},
 journal = {HEART AND VESSELS},
 month = {Jun},
 note = {The favorable effect of fish oils rich in n-3 polyunsaturated fatty acids (PUFAs) on the development of atrial fibrillation (AF) is controversial. The relationship between the serum concentrations of n-3 PUFAs and the incidence of AF is unclear; therefore, in the present study, we aimed to elucidate this relationship. We evaluated the serum concentrations of n-3 PUFAs in 110 patients with AF, 46 patients with ischemic heart disease (IHD) and no AF, and 36 healthy volunteers. Thirty-six patients had a history of IHD (IHD-AF group) and 74 did not (L-AF group). The eicosapentaenoic acid (EPA) levels in the L-AF group were higher than those in the IHD-AF and control groups (117 +/- A 64, 76 +/- A 30, and 68 +/- A 23 mu g/ml, respectively); the docosahexaenoic acid (DHA) levels showed the same pattern (170 +/- A 50, 127 +/- A 27, and 126 +/- A 35 mu g/ml, respectively). In both the L-AF and IHD-AF groups, the EPA levels in patients with persistent and permanent AF were higher than those in patients with paroxysmal AF (L-AF 131 +/- A 74 vs. 105 +/- A 51 mu g/ml; IHD-AF 82 +/- A 28 vs 70 +/- A 33 mu g/ml). Multivariate analysis showed that cases of AF were associated with higher levels of EPA but not DHA. In this Japanese population study, the EPA and DHA levels in patients with L-AF were higher than those in normal subjects. In particular, the EPA level was associated with the incidence of AF. These findings suggest that an excess of EPA might be a precipitating factor of AF., Article, HEART AND VESSELS. 28(4):497-504 (2013)},
 pages = {497--504},
 title = {High concentrations of omega-3 fatty acids are associated with the development of atrial fibrillation in the Japanese population},
 volume = {28},
 year = {2013}
}