@article{oai:soar-ir.repo.nii.ac.jp:00008049,
 author = {Maezawa,  Kayoko and Matsunaga,  Tamihide and Takezawa,  Takashi and Kanai,  Makoto and Ohira,  Satoshi and Ohmori,  Shigeru},
 issue = {2},
 journal = {BIOLOGICAL & PHARMACEUTICAL BULLETIN},
 month = {Feb},
 note = {Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. These CYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expression level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNA in the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the expression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically related protein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6 beta-hydroxylase activity in homogenate of human placenta, amnion and chorion/decidua were 26.6, 3.7 and 4.6 pmol/h/mg protein, respectively. These results suggest that CVP3As in fetal membranes have the metabolic function to protect the fetus from exposure to drugs., Article, BIOLOGICAL & PHARMACEUTICAL BULLETIN. 33(2):249-254 (2010)},
 pages = {249--254},
 title = {Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term},
 volume = {33},
 year = {2010}
}