{"created":"2021-03-01T06:11:54.322877+00:00","id":8049,"links":{},"metadata":{"_buckets":{"deposit":"c935534c-3097-43b0-8137-87120043764d"},"_deposit":{"id":"8049","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8049"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00008049","sets":["882:883"]},"author_link":["22279","22280","22281","22282","22283","22284"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"254","bibliographicPageStart":"249","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"BIOLOGICAL & PHARMACEUTICAL BULLETIN"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. These CYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expression level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNA in the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the expression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically related protein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6 beta-hydroxylase activity in homogenate of human placenta, amnion and chorion/decidua were 26.6, 3.7 and 4.6 pmol/h/mg protein, respectively. These results suggest that CVP3As in fetal membranes have the metabolic function to protect the fetus from exposure to drugs.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BIOLOGICAL & PHARMACEUTICAL BULLETIN. 33(2):249-254 (2010)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Kanai, Makoto","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.WVnNupkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274005600015"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PHARMACEUTICAL SOC JAPAN"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1248/bpb.33.249"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/bpb.33.249","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2010 The Pharmaceutical Society of Japan"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maezawa,  Kayoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsunaga,  Tamihide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takezawa,  Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanai,  Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohira,  Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohmori,  Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Cytochrome_P450_3As_Gene_Expression_Testosterone.pdf","filesize":[{"value":"267.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Cytochrome_P450_3As_Gene_Expression_Testosterone.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/8049/files/Cytochrome_P450_3As_Gene_Expression_Testosterone.pdf"},"version_id":"d75e2514-bdad-4631-9dfa-3340516043e6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cytochrome P450 3A","subitem_subject_scheme":"Other"},{"subitem_subject":"fetal membrane","subitem_subject_scheme":"Other"},{"subitem_subject":"amnion","subitem_subject_scheme":"Other"},{"subitem_subject":"chorion","subitem_subject_scheme":"Other"},{"subitem_subject":"decidua","subitem_subject_scheme":"Other"},{"subitem_subject":"testosterone 6 beta-hydroxylation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["883"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-04-23"},"publish_date":"2013-04-23","publish_status":"0","recid":"8049","relation_version_is_last":true,"title":["Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:00:35.466437+00:00"}