@article{oai:soar-ir.repo.nii.ac.jp:00008053,
 author = {Akaishi,  Kotaro and Nakayama,  Jun and Sakai,  Keiichi and Kobayashi,  Tatsuya and Rutka,  James T},
 issue = {12},
 journal = {JOURNAL OF CLINICAL NEUROSCIENCE},
 month = {Dec},
 note = {This study was performed to determine the relationship between p57/Kip2 and the growth of human astrocytomas. Immunohistochemical staining for p57/Kip2, p53, p16, and Ki67 antigen was performed on paraffin-embedded tissue specimens obtained from 36 patients with astrocytoma. Expression of p57/Kip2, p53, p16, and Ki67 antigen was generally increased in association with the astrocytoma tumor grade. Expression of p16 was higher in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells (p < 0.05). Expression of p53 also tended to be higher, but not to a statistically significant extent, in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells. These findings suggest that p57/Kip2 inhibits the growth of human astrocytomas, and may function in parallel with p16 and p53. However, p57/Kip2 is, by itself, insufficient to arrest the cellular proliferation of human astrocytomas., Article, JOURNAL OF CLINICAL NEUROSCIENCE. 16(12):1615-1618 (2009)},
 pages = {1615--1618},
 title = {Antigen p57/Kip2 as a potential negative regulator of human astrocytoma growth},
 volume = {16},
 year = {2009}
}