{"created":"2021-03-01T06:11:54.678728+00:00","id":8055,"links":{},"metadata":{"_buckets":{"deposit":"c843d213-8abc-4502-a145-a7f048399c83"},"_deposit":{"id":"8055","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8055"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00008055","sets":["882:883"]},"author_link":["22317","22318","22319","22320"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"173","bibliographicPageStart":"167","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"NEUROSURGICAL REVIEW"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prognosis of chordomas is difficult to predict based solely on histological findings. The purpose of this study was to assess expressions of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and matrix metalloproteinase (MMP)-2, MMP-9 in skull base chordomas and to find out their correlations to outcome. Immunohistochemical study was performed in 19 samples (initial, n = 11; recurrent, n = 8) from 11 patients. The correlations among expression of RECK, MMP-2, MMP-9, and their prognostic values were analyzed. Significant correlation between RECK and MMP-9 was found, but there was no correlation found between MMP-2 and MMP-9. Higher MMP-9 expression significantly influenced outcome. Furthermore, MMP-9/RECK ratio showed significant correlation to outcome, showing their inverse relationship in the disease progress of skull base chordoma. RECK and MMP-9 can be valuable markers to predict prognosis in skull base chordomas.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"NEUROSURGICAL REVIEW. 33(2):167-173 (2010)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Nakayama, Jun","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html"},{"subitem_link_text":"Hongo, Kazuhiro","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jecFHCkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000275472200009"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SPRINGER"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"19862564"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/19862564","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1007/s10143-009-0228-y"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10143-009-0228-y","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0344-5607","subitem_source_identifier_type":"EISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00324143","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rahmah,  Nunung Nur","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai,  Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama,  Jun","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hongo,  Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Reversion-inducing_cysteine-rich_protein_kazal_motifs_matrix_metalloproteinase-9.pdf","filesize":[{"value":"137.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Reversion-inducing_cysteine-rich_protein_kazal_motifs_matrix_metalloproteinase-9.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/8055/files/Reversion-inducing_cysteine-rich_protein_kazal_motifs_matrix_metalloproteinase-9.pdf"},"version_id":"77949c76-f510-4da9-b525-95354e743ffb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Skull base chordomas","subitem_subject_scheme":"Other"},{"subitem_subject":"RECK","subitem_subject_scheme":"Other"},{"subitem_subject":"MMP-2","subitem_subject_scheme":"Other"},{"subitem_subject":"MMP-9","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["883"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-04-23"},"publish_date":"2013-04-23","publish_status":"0","recid":"8055","relation_version_is_last":true,"title":["Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:00:44.646676+00:00"}