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Peripheral nerve involvement in primary systemic AL amyloidosis: a clinical and electrophysiological study
http://hdl.handle.net/10091/16894
http://hdl.handle.net/10091/168948e8cd929-f7ae-4af9-9b44-bf274355b7e0
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-01 | |||||
タイトル | ||||||
タイトル | Peripheral nerve involvement in primary systemic AL amyloidosis: a clinical and electrophysiological study | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
関連識別子 | https://doi.org/10.1111/j.1468-1331.2010.03215.x | |||||
関連名称 | 10.1111/j.1468-1331.2010.03215.x | |||||
キーワード | ||||||
主題 | AL amyloidosis, autonomic nerve dysfunction, carpal tunnel syndrome, polyneuropathy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuda, M
× Matsuda, M× Gono, T× Morita, H× Katoh, N× Kodaira, M× Ikeda, S |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Morita, H | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Katoh, N | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.yFTpgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Kodaira, M | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.jmfUgUkh.html | |||||
出版者 | ||||||
出版者 | WILEY-BLACKWELL | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EUROPEAN JOURNAL OF NEUROLOGY. 18(4):604-610 (2011) | |||||
書誌情報 |
EUROPEAN JOURNAL OF NEUROLOGY 巻 18, 号 4, p. 604-610, 発行日 2011-04 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Involvement of visceral organs usually dominates the clinical picture of primary systemic AL amyloidosis, but some patients suffer from serious peripheral neuropathy. The aim of this study is to clinically and electrophysiologically investigate peripheral nerve involvement in AL amyloidosis patients. Patients and methods: We reviewed clinical manifestations, electrophysiological findings including nerve conduction velocities and treatments in 43 consecutive patients. Twenty age-matched healthy subjects were employed as controls. Results: Fifteen patients (34.9%) showed apparent neuropathic symptoms, which consisted of polyneuropathy in 11 (25.6%), bilateral carpal tunnel syndrome in 4 (9.3%), and autonomic dysfunction in 8 (18.6%). Polyneuropathy in this disease was characterized by symmetrical and sensory-dominant impairment, early involvement of the lower limbs, loss of all sensations, rarity of motor weakness, and painful paresthesia in the legs predominant at an early stage. Autonomic dysfunction including orthostatic hypotension was frequently associated with polyneuropathy at an advanced stage. On electrophysiological studies, motor conduction velocity and compound muscle action potential of both median and tibial nerves were significantly decreased in the patients with polyneuropathy but also in those without any signs of neuropathy. Only four of 15 patients with neuropathy were able to receive intensive but promising chemotherapy with a large dose of melphalan for plasma cell dyscrasia. Conclusions: Peripheral nerves in primary systemic AL amyloidosis patients seem to be involved more extensively than clinical manifestations might suggest. The clinical picture of polyneuropathy in this disease closely resembles that in transthyretin-type familial amyloid polyneuropathy patients with a late age at onset, particularly those originating from sporadic kindreds. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1351-5101 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11015934 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20860753 | |||||
関連名称 | 20860753 | |||||
権利 | ||||||
権利情報 | The definitive version is available at wileyonlinelibrary.com. | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000288503600015 |