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  1. 055 医学部附属病院
  2. 0551 学術論文

Peripheral nerve involvement in primary systemic AL amyloidosis: a clinical and electrophysiological study

http://hdl.handle.net/10091/16894
http://hdl.handle.net/10091/16894
8e8cd929-f7ae-4af9-9b44-bf274355b7e0
名前 / ファイル ライセンス アクション
Peripheral_nerve_involvement_primary_systemic_AL_amyloidosis.pdf Peripheral_nerve_involvement_primary_systemic_AL_amyloidosis.pdf (127.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-01
タイトル
言語 en
タイトル Peripheral nerve involvement in primary systemic AL amyloidosis: a clinical and electrophysiological study
言語
言語 eng
キーワード
主題Scheme Other
主題 AL amyloidosis
キーワード
主題Scheme Other
主題 autonomic nerve dysfunction
キーワード
主題Scheme Other
主題 carpal tunnel syndrome
キーワード
主題Scheme Other
主題 polyneuropathy
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Matsuda, M

× Matsuda, M

WEKO 22349

en Matsuda, M

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Gono, T

× Gono, T

WEKO 22350

en Gono, T

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Morita, H

× Morita, H

WEKO 22351

en Morita, H

Search repository
Katoh, N

× Katoh, N

WEKO 22352

en Katoh, N

Search repository
Kodaira, M

× Kodaira, M

WEKO 22353

en Kodaira, M

Search repository
Ikeda, S

× Ikeda, S

WEKO 22354

en Ikeda, S

Search repository
信州大学研究者総覧へのリンク
氏名 Morita, H
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html
信州大学研究者総覧へのリンク
氏名 Katoh, N
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.yFTpgpkh.html
信州大学研究者総覧へのリンク
氏名 Kodaira, M
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jmfUgUkh.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 EUROPEAN JOURNAL OF NEUROLOGY. 18(4):604-610 (2011)
書誌情報 EUROPEAN JOURNAL OF NEUROLOGY

巻 18, 号 4, p. 604-610, 発行日 2011-04
抄録
内容記述タイプ Abstract
内容記述 Background: Involvement of visceral organs usually dominates the clinical picture of primary systemic AL amyloidosis, but some patients suffer from serious peripheral neuropathy. The aim of this study is to clinically and electrophysiologically investigate peripheral nerve involvement in AL amyloidosis patients. Patients and methods: We reviewed clinical manifestations, electrophysiological findings including nerve conduction velocities and treatments in 43 consecutive patients. Twenty age-matched healthy subjects were employed as controls. Results: Fifteen patients (34.9%) showed apparent neuropathic symptoms, which consisted of polyneuropathy in 11 (25.6%), bilateral carpal tunnel syndrome in 4 (9.3%), and autonomic dysfunction in 8 (18.6%). Polyneuropathy in this disease was characterized by symmetrical and sensory-dominant impairment, early involvement of the lower limbs, loss of all sensations, rarity of motor weakness, and painful paresthesia in the legs predominant at an early stage. Autonomic dysfunction including orthostatic hypotension was frequently associated with polyneuropathy at an advanced stage. On electrophysiological studies, motor conduction velocity and compound muscle action potential of both median and tibial nerves were significantly decreased in the patients with polyneuropathy but also in those without any signs of neuropathy. Only four of 15 patients with neuropathy were able to receive intensive but promising chemotherapy with a large dose of melphalan for plasma cell dyscrasia. Conclusions: Peripheral nerves in primary systemic AL amyloidosis patients seem to be involved more extensively than clinical manifestations might suggest. The clinical picture of polyneuropathy in this disease closely resembles that in transthyretin-type familial amyloid polyneuropathy patients with a late age at onset, particularly those originating from sporadic kindreds.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1351-5101
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11015934
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20860753
関連名称 20860753
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1468-1331.2010.03215.x
関連名称 10.1111/j.1468-1331.2010.03215.x
権利
権利情報 The definitive version is available at wileyonlinelibrary.com.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000288503600015
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