@article{oai:soar-ir.repo.nii.ac.jp:00008067,
 author = {Yoshizawa,  Kaname and Umemura,  Takeji and Ota,  Masao},
 issue = {1},
 journal = {JOURNAL OF GASTROENTEROLOGY},
 month = {Jan},
 note = {Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Several studies from ethnically different countries have clarified that the genetic predisposition to type 1 AIH is linked mainly to human leukocyte antigen (HLA)-class II genes. Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic beta chain of the HLA-DR antigen. However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis., Article, JOURNAL OF GASTROENTEROLOGY. 46(1):42-47 (2011)},
 pages = {42--47},
 title = {Genetic background of autoimmune hepatitis in Japan},
 volume = {46},
 year = {2011}
}