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Unlike the V/FIV family, the Otsu propositus showed no thrombotic tendencies. To analyze the relationship between thrombosis and the heterozygous plasma variant fibrinogen, we used purified plasma fibrinogen from the Otsu patient and compared it with a normal control. Materials and methods: Thrombin-induced fibrin clot formation and clot structure were observed by fibrin polymerization and scanning electron microscopy, respectively. For in vitro observation of fibrinolysis, plasmin generation and clot lysis assays were performed by the addition of tissue type plasminogen activation (tPA) and plasminogen. Results and conclusions: Polymerization of Otsu was markedly impaired, while fibrin fibers were much thicker and the density of the bundles of fibrin fibers was less and porous compared with normal. Lysis of the Otsu clot was not significantly different from normal when a tPA and plasminogen mixture was overlaid onto the clots. For Otsu, the penetration of the tPA/plasminogen mixture into the clot was much faster than normal and the protection against plasmin cleavage was impaired; however, tPA-induced plasmin activation of the Otsu fibrin was slower than that of normal fibrin, resulting in a clot lysis of Otsu similar to normal. (c) 2005 Elsevier Ltd. All rigths reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Terasawa, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8471", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kani, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hongo, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8474", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Thromb_Res-Terasawa.pdf", "filesize": [{"value": "498.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 498300.0, "url": {"label": "Thromb_Res-Terasawa.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3991/files/Thromb_Res-Terasawa.pdf"}, "version_id": "186d2a83-3c1d-49a6-a02a-03d674ecf0a1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1004", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-02-22"}, "publish_date": "2008-02-22", "publish_status": "0", "recid": "3991", "relation": {}, "relation_version_is_last": true, "title": ["In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I"], "weko_shared_id": -1}
In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I
http://hdl.handle.net/10091/1004
http://hdl.handle.net/10091/1004857bd838-8adf-4f87-950e-2f5ea83aa8cf
名前 / ファイル | ライセンス | アクション |
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Thromb_Res-Terasawa.pdf (498.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-02-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.thromres.2005.10.013 | |||||
関連名称 | 10.1016/j.thromres.2005.10.013 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Terasawa, F
× Terasawa, F× Kani, S× Hongo, M× Okumura, N |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Okumura, N | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html | |||||
出版者 | ||||||
出版者 | PERGAMON-ELSEVIER SCIENCE LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | THROMBOSIS RESEARCH. 118(5): 651-661 (2006) | |||||
書誌情報 |
Thrombosis research 巻 118, 号 5, p. 651-661, 発行日 2006 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0049-3848 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863148 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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