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Unlike the V/FIV family, the Otsu propositus showed no thrombotic tendencies. To analyze the relationship between thrombosis and the heterozygous plasma variant fibrinogen, we used purified plasma fibrinogen from the Otsu patient and compared it with a normal control. Materials and methods: Thrombin-induced fibrin clot formation and clot structure were observed by fibrin polymerization and scanning electron microscopy, respectively. For in vitro observation of fibrinolysis, plasmin generation and clot lysis assays were performed by the addition of tissue type plasminogen activation (tPA) and plasminogen. Results and conclusions: Polymerization of Otsu was markedly impaired, while fibrin fibers were much thicker and the density of the bundles of fibrin fibers was less and porous compared with normal. Lysis of the Otsu clot was not significantly different from normal when a tPA and plasminogen mixture was overlaid onto the clots. For Otsu, the penetration of the tPA/plasminogen mixture into the clot was much faster than normal and the protection against plasmin cleavage was impaired; however, tPA-induced plasmin activation of the Otsu fibrin was slower than that of normal fibrin, resulting in a clot lysis of Otsu similar to normal. (c) 2005 Elsevier Ltd. All rigths reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Terasawa,  F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8471", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kani,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hongo,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8474", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Thromb_Res-Terasawa.pdf", "filesize": [{"value": "498.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 498300.0, "url": {"label": "Thromb_Res-Terasawa.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3991/files/Thromb_Res-Terasawa.pdf"}, "version_id": "186d2a83-3c1d-49a6-a02a-03d674ecf0a1"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/1004", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-02-22"}, "publish_date": "2008-02-22", "publish_status": "0", "recid": "3991", "relation": {}, "relation_version_is_last": true, "title": ["In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I

http://hdl.handle.net/10091/1004
857bd838-8adf-4f87-950e-2f5ea83aa8cf
名前 / ファイル ライセンス アクション
Thromb_Res-Terasawa.pdf Thromb_Res-Terasawa.pdf (498.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-02-22
タイトル
言語 en
タイトル In vitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gamma Asn319, Asp320 deletion dysfibrinogen, Otsu I
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Terasawa, F

× Terasawa, F

WEKO 8471

en Terasawa, F

Search repository
Kani, S

× Kani, S

WEKO 8472

en Kani, S

Search repository
Hongo, M

× Hongo, M

WEKO 8473

en Hongo, M

Search repository
Okumura, N

× Okumura, N

WEKO 8474

en Okumura, N

Search repository
信州大学研究者総覧へのリンク
氏名 Okumura, N
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html
出版者
出版者 PERGAMON-ELSEVIER SCIENCE LTD
引用
内容記述タイプ Other
内容記述 THROMBOSIS RESEARCH. 118(5): 651-661 (2006)
書誌情報 Thrombosis research

巻 118, 号 5, p. 651-661, 発行日 2006
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0049-3848
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00863148
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.thromres.2005.10.013
関連名称
関連名称 10.1016/j.thromres.2005.10.013
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000241430200012
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