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Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
http://hdl.handle.net/10091/13513
http://hdl.handle.net/10091/13513d58b9ddf-f5d6-426a-a494-093fa9fbd399
名前 / ファイル | ライセンス | アクション |
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Elucidation_mechanism_different_biological_responses.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-01-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2147/IJN.S26689 | |||||
関連名称 | 10.2147/IJN.S26689 | |||||
キーワード | ||||||
主題 | ulti-walled carbon nanotubes, cytotoxicity, endocytosis, cytokine secretion, reactive oxygen species | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Haniu, Hisao
× Haniu, Hisao× Saito, Naoto× Matsuda, Yoshikazu× Kim, Yoong-Ahm× Park, Ki Chul× Tsukahara, Tamotsu× Usui, Yuki× Aoki, Kaoru× Shimizu, Masayuki× Ogihara, Nobuhide× Hara, Kazuo× Takanashi, Seiji× Okamoto, Masanori× Ishigaki, Norio× Nakamura, Koichi× Kato, Hiroyuki |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Haniu, Hisao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Saito, Naoto | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kato, Hiroyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html | |||||
出版者 | ||||||
出版者 | Dove Medical Press | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Nanomedicine. 6(1):3487-3497 (2011) | |||||
書誌情報 |
International Journal of Nanomedicine 巻 1, 号 6, p. 3487-3497, 発行日 2011-12-21 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined differences in cellular responses to multi-walled carbon nanotubes (MWCNTs) using malignant pleural mesothelioma cells (MESO-1), bronchial epithelial cells (BEAS-2B), neuroblastoma cells (IMR-32), and monoblastic cells (THP-1), before and after differentiation. MESO-1, BEAS-2B and differentiated THP-1 cells actively endocytosed MWCNTs, resulting in cytotoxicity with lysosomal injury. However, cytotoxicity did not occur in IMR-32 or undifferentiated THP-1 cells. Both differentiated and undifferentiated THP-1 cells exhibited an inflammatory response. Carbon blacks were endocytosed by the same cell types without lysosomal damage and caused cytokine secretion, but they did not cause cytotoxicity. These results indicate that the cytotoxicity of MWCNTs requires not only cellular uptake but also lysosomal injury. Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1176-9114 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1215861X | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22267932/ | |||||
関連名称 | 22267932 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000298288600001 |