WEKO3
アイテム
{"_buckets": {"deposit": "f29b21f5-f0f3-465a-853f-4fe0e5ffbfe5"}, "_deposit": {"id": "3936", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3936"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003936", "sets": ["462"]}, "author_link": ["8128", "8129", "8130", "8131", "8132", "8133"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "55", "bibliographicPageStart": "49", "bibliographicVolumeNumber": "42", "bibliographic_titles": [{"bibliographic_title": "JOURNAL OF GASTROENTEROLOGY"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The original publication is available at www.springerlink.com", "subitem_description_type": "Other"}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background and Purpose Iron reduction therapy (IRT) has been recognized as beneficial for chronic hepatitis C patients. However, its efficacy for hepatitis C virus-related liver cirrhosis (LC-C) has not been elucidated. We aimed to evaluate the efficacy and safety of IRT for LC-C patients. Methods Twenty-two LC-C patients were treated with biweekly phlebotomy and low iron diet for 6 months, in addition to regular hepatoprotective therapy. Nineteen sex- and age-matched patients who refused to receive IRT were used as controls. The efficacy of IRT was evaluated based on biochemical parameters. Results Of 22 patients receiving IRT, 19 completed the 6-month treatment. IRT significantly reduced serum levels of aspartate aminotransferase (from 89 to 57 U/L; P = 0.003), alanine aminotransferase (from 101 to 54 U/L; P \u003c 0.001), and alpha-fetoprotein (from 28 to 12 ng/mL; P = 0.003). These changes were not observed in the controls. Two patients whose serum albumin concentrations were less than 3.6 g/dL at the beginning of IRT withdrew from IRT because of a new appearance of ascites. Conclusions IRT improved the serum levels of aminotransferases and alpha-fetoprotein for LC-C patients, and was generally safe; however, IRT should be performed in patients who maintain serum albumin concentrations of more than 3.6 g/dL.", "subitem_description_type": "Abstract"}]}, "item_6_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF GASTROENTEROLOGY 42(1): 49-55(2007)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Tanaka, Eiji", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000244483900006"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER TOKYO"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "17322993"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/17322993", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00535-006-1967-y"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00535-006-1967-y", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0944-1174", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0944-1174", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10988015", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "iron reduction therapy; HCV-related cirrhosis; alpha-fetoprotein; albumin; protein-energy malnutrition"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "HEPATOCELLULAR-CARCINOMA DEVELOPMENT; ALANINE AMINOTRANSFERASE LEVELS; LIVER-CIRRHOSIS; OVERLOAD; PHLEBOTOMY; DISEASE; MECHANISMS; INFECTION; SURVIVAL; DIET"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background Iron reduction therapy (IRT) has been recognized as beneficial for chronic hepatitis C patients. However, its efficacy for hepatitis C virus-related liver cirrhosis (LC-C) has not been elucidated. We evaluated the efficacy and safety of IRT for LC-C patients. Methods Twenty-two LC-C patients were treated with biweekly phlebotomy and low iron diet for 6 months, in addition to regular hepatoprotective therapy. Nineteen sex- and age-matched patients who refused to receive IRT were used as controls. The efficacy of IRT was evaluated on the basis of biochemical parameters. Results Of 22 patients receiving IRT, 19 completed the 6-month treatment. IRT significantly reduced serum levels of aspartate aminotransferase (from 89 to 57U/L; P = 0.003), alanine aminotransferase (from 101 to 54U/L; P \u003c 0.001), and alpha-fetoprotein (from 28 to 12g/mL; P = 0.003). These changes were not observed in the controls. Two patients whose serum albumin concentrations were less than 3.6g/dL at the beginning of IRT withdrew from IRT because of the new appearance of ascites. Conclusions IRT improved the serum levels of aminotransferases and alpha-fetoprotein in LC-C patients and was generally safe; however, IRT should be performed in patients who maintain serum albumin concentrations of more than 3.6g/dL."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tanaka, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8128", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horiuchi, Akira", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8129", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaura, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8130", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Michiharu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8131", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Eiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8132", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa, Kendo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8133", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PhlebotomyforLC-C_JGR1.pdf", "filesize": [{"value": "108.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 108500.0, "url": {"label": "PhlebotomyforLC-C_JGR1.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3936/files/PhlebotomyforLC-C_JGR1.pdf"}, "version_id": "8e90860e-5525-41f0-b2f9-5d77147c9e2a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "iron reduction therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HCV-related cirrhosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "α-fetoprotein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "albumin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protein-energy malnutrition", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/3106", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-06-18"}, "publish_date": "2009-06-18", "publish_status": "0", "recid": "3936", "relation": {}, "relation_version_is_last": true, "title": ["Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study"], "weko_shared_id": -1}
Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
http://hdl.handle.net/10091/3106
http://hdl.handle.net/10091/310694e4c204-eade-4290-a2f5-bdd95095850e
名前 / ファイル | ライセンス | アクション |
---|---|---|
PhlebotomyforLC-C_JGR1.pdf (108.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-06-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00535-006-1967-y | |||||
関連名称 | 10.1007/s00535-006-1967-y | |||||
キーワード | ||||||
主題 | iron reduction therapy, HCV-related cirrhosis, α-fetoprotein, albumin, protein-energy malnutrition | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tanaka, Naoki
× Tanaka, Naoki× Horiuchi, Akira× Yamaura, Takahiro× Komatsu, Michiharu× Tanaka, Eiji× Kiyosawa, Kendo |
|||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, Eiji | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | SPRINGER TOKYO | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF GASTROENTEROLOGY 42(1): 49-55(2007) | |||||
書誌情報 |
JOURNAL OF GASTROENTEROLOGY 巻 42, 号 1, p. 49-55, 発行日 2007-01 |
|||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and Purpose Iron reduction therapy (IRT) has been recognized as beneficial for chronic hepatitis C patients. However, its efficacy for hepatitis C virus-related liver cirrhosis (LC-C) has not been elucidated. We aimed to evaluate the efficacy and safety of IRT for LC-C patients. Methods Twenty-two LC-C patients were treated with biweekly phlebotomy and low iron diet for 6 months, in addition to regular hepatoprotective therapy. Nineteen sex- and age-matched patients who refused to receive IRT were used as controls. The efficacy of IRT was evaluated based on biochemical parameters. Results Of 22 patients receiving IRT, 19 completed the 6-month treatment. IRT significantly reduced serum levels of aspartate aminotransferase (from 89 to 57 U/L; P = 0.003), alanine aminotransferase (from 101 to 54 U/L; P < 0.001), and alpha-fetoprotein (from 28 to 12 ng/mL; P = 0.003). These changes were not observed in the controls. Two patients whose serum albumin concentrations were less than 3.6 g/dL at the beginning of IRT withdrew from IRT because of a new appearance of ascites. Conclusions IRT improved the serum levels of aminotransferases and alpha-fetoprotein for LC-C patients, and was generally safe; however, IRT should be performed in patients who maintain serum albumin concentrations of more than 3.6 g/dL. | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0944-1174 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10988015 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/17322993 | |||||
関連名称 | 17322993 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000244483900006 |