Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2009-06-18 |
タイトル |
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タイトル |
Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00535-006-1967-y |
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関連名称 |
10.1007/s00535-006-1967-y |
キーワード |
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主題 |
iron reduction therapy, HCV-related cirrhosis, α-fetoprotein, albumin, protein-energy malnutrition |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Tanaka, Naoki
Horiuchi, Akira
Yamaura, Takahiro
Komatsu, Michiharu
Tanaka, Eiji
Kiyosawa, Kendo
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信州大学研究者総覧へのリンク |
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氏名 |
Tanaka, Eiji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html |
出版者 |
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出版者 |
SPRINGER TOKYO |
引用 |
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内容記述 |
JOURNAL OF GASTROENTEROLOGY 42(1): 49-55(2007) |
書誌情報 |
JOURNAL OF GASTROENTEROLOGY
巻 42,
号 1,
p. 49-55,
発行日 2007-01
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内容記述 |
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内容記述 |
The original publication is available at www.springerlink.com |
抄録 |
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内容記述 |
Background and Purpose Iron reduction therapy (IRT) has been recognized as beneficial for chronic hepatitis C patients. However, its efficacy for hepatitis C virus-related liver cirrhosis (LC-C) has not been elucidated. We aimed to evaluate the efficacy and safety of IRT for LC-C patients. Methods Twenty-two LC-C patients were treated with biweekly phlebotomy and low iron diet for 6 months, in addition to regular hepatoprotective therapy. Nineteen sex- and age-matched patients who refused to receive IRT were used as controls. The efficacy of IRT was evaluated based on biochemical parameters. Results Of 22 patients receiving IRT, 19 completed the 6-month treatment. IRT significantly reduced serum levels of aspartate aminotransferase (from 89 to 57 U/L; P = 0.003), alanine aminotransferase (from 101 to 54 U/L; P < 0.001), and alpha-fetoprotein (from 28 to 12 ng/mL; P = 0.003). These changes were not observed in the controls. Two patients whose serum albumin concentrations were less than 3.6 g/dL at the beginning of IRT withdrew from IRT because of a new appearance of ascites. Conclusions IRT improved the serum levels of aminotransferases and alpha-fetoprotein for LC-C patients, and was generally safe; however, IRT should be performed in patients who maintain serum albumin concentrations of more than 3.6 g/dL. |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0944-1174 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10988015 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/17322993 |
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関連名称 |
17322993 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000244483900006 |