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To characterize the phenotypic patterns of differentiation in colorectal serrated polyps, we examined the immunohistochemical expression profile of gastric (MUC5AC, TFF1, MUC6, GlcNAc alpha 1 -\u003e 4Gal -\u003e R, and PDX1) and intestinal (MUC2, TFF3, and CDX2) epithelial markers in 15 hyperplastic polyps (HPs), 29 sessile serrated adenomas (SSAs), 12 traditional serrated adenomas (TSAs), and 16 conventional adenomas (CAs). MUC5AC and TFF1 were upregulated in the HPs, SSAs, and TSAs. MUC6 was expressed in the HPs and SSAs, GlcNAc alpha 1 -\u003e 4Gal -\u003e R was expressed only in the SSAs. Although MUC2 expression was preserved, TFF3 was downregulated in the HPs, SSAs, and TSAs. PDX1 was upregulated in the HPs, SSAs, and TSAs. On the other hand, CDX2 was downregulated in the HPs and SSAs. The colorectal serrated polyps showed higher expression of gastric makers than CAs. The HPs and SSAs showed gastric and intestinal mixed phenotype expression with gastric pyloric organoid differentiation and almost identical, but different from the TSAs, marker profile. PDX1 up-regulation and CDX2 down-regulation could be important for the induction of a gastric pyloric pattern of cell differentiation in colorectal serrated polyps."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mochizuka, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8608", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uehara, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8609", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8610", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8612", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "HCB-0737-07-Roth.pdf", "filesize": [{"value": "430.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 430900.0, "url": {"label": "HCB-0737-07-Roth.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4015/files/HCB-0737-07-Roth.pdf"}, "version_id": "6ec2230a-a78a-4850-9906-7b5b3f2e9e6e"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hyperplastic polyps and sessile serrated \u0027adenomas\u0027 of the colon and rectum display gastric pyloric differentiation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hyperplastic polyps and sessile serrated \u0027adenomas\u0027 of the colon and rectum display gastric pyloric differentiation", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/732", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-11-29"}, "publish_date": "2007-11-29", "publish_status": "0", "recid": "4015", "relation": {}, "relation_version_is_last": true, "title": ["Hyperplastic polyps and sessile serrated \u0027adenomas\u0027 of the colon and rectum display gastric pyloric differentiation"], "weko_shared_id": -1}
Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation
http://hdl.handle.net/10091/732
http://hdl.handle.net/10091/732a895791e-6e15-433d-80ef-c6520d896b94
名前 / ファイル | ライセンス | アクション |
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HCB-0737-07-Roth.pdf (430.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-11-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00418-007-0326-2 | |||||
関連名称 | 10.1007/s00418-007-0326-2 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Mochizuka, A
× Mochizuka, A× Uehara, T× Nakamura, T× Kobayashi, Y× Ota, H |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, H | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WNkCHhkh.html | |||||
出版者 | ||||||
出版者 | Springer | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Histochemistry and Cell Biology. 128(5): 445-455 (2007) | |||||
書誌情報 |
Histochemistry and Cell Biology 巻 128, 号 5, p. 445-455, 発行日 2007-11 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | “The original publication is available at www.springerlink.com.” | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0948-6143 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11033302 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000249807600007 |