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To characterize the phenotypic patterns of differentiation in colorectal serrated polyps, we examined the immunohistochemical expression profile of gastric (MUC5AC, TFF1, MUC6, GlcNAc alpha 1 -\u003e 4Gal -\u003e R, and PDX1) and intestinal (MUC2, TFF3, and CDX2) epithelial markers in 15 hyperplastic polyps (HPs), 29 sessile serrated adenomas (SSAs), 12 traditional serrated adenomas (TSAs), and 16 conventional adenomas (CAs). MUC5AC and TFF1 were upregulated in the HPs, SSAs, and TSAs. MUC6 was expressed in the HPs and SSAs, GlcNAc alpha 1 -\u003e 4Gal -\u003e R was expressed only in the SSAs. Although MUC2 expression was preserved, TFF3 was downregulated in the HPs, SSAs, and TSAs. PDX1 was upregulated in the HPs, SSAs, and TSAs. On the other hand, CDX2 was downregulated in the HPs and SSAs. The colorectal serrated polyps showed higher expression of gastric makers than CAs. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation

http://hdl.handle.net/10091/732
a895791e-6e15-433d-80ef-c6520d896b94
名前 / ファイル ライセンス アクション
HCB-0737-07-Roth.pdf HCB-0737-07-Roth.pdf (430.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-11-29
タイトル
言語 en
タイトル Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Mochizuka, A

× Mochizuka, A

WEKO 8608

en Mochizuka, A

Search repository
Uehara, T

× Uehara, T

WEKO 8609

en Uehara, T

Search repository
Nakamura, T

× Nakamura, T

WEKO 8610

en Nakamura, T

Search repository
Kobayashi, Y

× Kobayashi, Y

WEKO 8611

en Kobayashi, Y

Search repository
Ota, H

× Ota, H

WEKO 8612

en Ota, H

Search repository
信州大学研究者総覧へのリンク
氏名 Ota, H
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WNkCHhkh.html
出版者
出版者 Springer
引用
内容記述タイプ Other
内容記述 Histochemistry and Cell Biology. 128(5): 445-455 (2007)
書誌情報 Histochemistry and Cell Biology

巻 128, 号 5, p. 445-455, 発行日 2007-11
内容記述
内容記述タイプ Other
内容記述 “The original publication is available at www.springerlink.com.”
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0948-6143
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11033302
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00418-007-0326-2
関連名称
関連名称 10.1007/s00418-007-0326-2
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000249807600007
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