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Blood Pressure-Lowering Peptides from Neo-Fermented Buckwheat Sprouts: A New Approach to Estimating ACE-Inhibitory Activity
http://hdl.handle.net/10091/18105
http://hdl.handle.net/10091/1810589477e9e-e2c7-489d-933e-3c2c772c8116
| 名前 / ファイル | ライセンス | アクション |
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Blood_Pressure-Lowering_Peptides.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-02-18 | |||||
| タイトル | ||||||
| タイトル | Blood Pressure-Lowering Peptides from Neo-Fermented Buckwheat Sprouts: A New Approach to Estimating ACE-Inhibitory Activity | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0105802 | |||||
| 関連名称 | 10.1371/journal.pone.0105802 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Koyama, Masahiro
× Koyama, Masahiro× Hattori, Seiji× Amano, Yoshihiko× Watanabe, Masanori× Nakamura, Kozo |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Amano, Yoshihiko | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gVTVZVkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Nakamura, Kozo | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.upyCPUkh.html | |||||
| 出版者 | ||||||
| 出版者 | PUBLIC LIBRARY SCIENCE | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PLOS ONE. 9(9):e105802 (2014) | |||||
| 書誌情報 |
PLOS ONE 巻 9, 号 9, p. e105802, 発行日 2014-09-15 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Neo-fermented buckwheat sprouts (neo-FBS) contain angiotensin-converting enzyme (ACE) inhibitors and vasodilators with blood pressure-lowering (BPL) properties in spontaneously hypertensive rats (SHRs). In this study, we investigated antihypertensive mechanisms of six BPL peptides isolated from neo-FBS (FBPs) by a vasorelaxation assay and conventional in vitro, in vivo, and a new ex vivo ACE inhibitory assays. Some FBPs demonstrated moderate endothelium-dependent vasorelaxation in SHR thoracic aorta and all FBPs mildly inhibited ACE in vitro. Orally administered FBPs strongly inhibited ACE in SHR tissues. To investigate detailed ACE-inhibitory mechanism of FBPs in living body tissues, we performed the ex vivo assay by using endothelium-denuded thoracic aorta rings isolated from SHRs, which demonstrated that FBPs at low concentration effectively inhibited ACE in thoracic aorta tissue and suppressed angiotensin II-mediated vasoconstriction directly associated with BPL. These results indicate that the main BPL mechanism of FBP was ACE inhibition in living body tissues, suggesting that high FBP's bioavailability including absorption, tissue affinity, and tissue accumulation was responsible for the superior ACE inhibition in vivo. We propose that our ex vivo assay is an efficient and reliable method for evaluating ACE-inhibitory mechanism responsible for BPL activity in vivo. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1932-6203 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/25222748/ | |||||
| 関連名称 | 25222748 | |||||
| 権利 | ||||||
| 権利情報 | Copyright: © 2014 Koyama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000341774800006 | |||||
