Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2015-02-12 |
タイトル |
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タイトル |
Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1038/mt.2014.239 |
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関連名称 |
10.1038/mt.2014.239 |
キーワード |
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主題 |
atopic dermatitis, iODN, nanocapsule, oral delivery, Peyer’s patch, macrophage |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Wang, Yeqin
Yamamoto, Yoshinari
Shigemori, Suguru
Watanabe, Takafumi
Oshiro, Kazushi
Wang, Xinyu
Wang, Pengfei
Sato, Takashi
Yonekura, Shinichi
Tanaka, Sachi
Kitazawa, Haruki
Shimosato, Takeshi
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信州大学研究者総覧へのリンク |
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氏名 |
Yonekura, Shinichi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gakFPUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Tanaka, Sachi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpACPUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Shimosato, Takeshi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html |
出版者 |
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出版者 |
NATURE PUBLISHING GROUP |
引用 |
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内容記述 |
MOLECULAR THERAPY. 23(2):297-309 (2015) |
書誌情報 |
MOLECULAR THERAPY
巻 23,
号 2,
p. 297-309,
発行日 2015-02
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内容記述 |
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内容記述 |
Advance online publication 6 January 2015 |
抄録 |
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内容記述 |
Here, we report a simple and low-cost oral oligodeoxynucleotide (ODN) delivery system targeted to the gut Peyer's patches (PPs). This system requires only Dulbecco's modified eagle's medium, calcium chloride, ODNs, and basic laboratory equipment. ODN nanocapsules (ODNcaps) were directly delivered to the PPs through oral administration and were taken up by macrophages in the PPs, where they induced an immune response. Long-term continuous oral dosing with inhibitory/suppressive ODNcaps (iODNcaps, "iSG3caps" in this study) was evaluated using an atopic dermatitis mouse model to visually monitor disease course. Administration of iSG3caps improved skin lesions and decreased epidermal thickness. Underlying this effect is the ability of iSG3 to bind to and prevent phosphorylation of signal transducer and activator of transcription 6, thereby blocking the interleukin-4 signaling cascade mediated by binding of allergens to type 2 helper T cells. The results of our iSG3cap oral delivery experiments suggest that iSG3 may be useful for treating allergic diseases. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1525-0016 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11475060 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/25502904/ |
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関連名称 |
25502904 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000348750700011 |