Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-09-05 |
タイトル |
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タイトル |
Ultrastructural Study on Colocalization of Glucagon-Like Peptide (GLP)-1 with GLP-2 in Chicken Intestinal L-Cells |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1292/jvms.13-0106 |
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関連名称 |
10.1292/jvms.13-0106 |
キーワード |
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主題 |
chicken, glucagon-like peptides, immunocytochemistry, immunohistochemistry, small intestine |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Nishimura, Kei
Hiramatsu, Kohzy
Monir, Mohammad M.
Takemoto, Chihiro
Watanabe, Takafumi
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信州大学研究者総覧へのリンク |
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氏名 |
Hiramatsu, Kohzy |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yeTmPpkh.html |
出版者 |
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出版者 |
JAPAN SOC VET SCI |
引用 |
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内容記述 |
JOURNAL OF VETERINARY MEDICAL SCIENCE. 75(10):1335-1339 (2013) |
書誌情報 |
JOURNAL OF VETERINARY MEDICAL SCIENCE
巻 75,
号 10,
p. 1335-1339,
発行日 2013-10
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抄録 |
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内容記述 |
Colocalization of glucagon-like peptide (GLP)-1 with GLP-2 in L-cells was investigated in the chicken ileum by using double immunofluorescent and immunocytochemical techniques. Ultrastructural features of L-cells were also clarified in this study. L-cells showing immunoreactivity for both GLP-1 and GLP-2 were distributed in the whole ileum. They showed comma-like or flask-like shape and were located in epithelium of crypts and lower part of intestinal villi. L-cells showing GLP-1-immunoreactivity only were found in epithelium of lower and middle parts of intestinal villi. Transmission electron microscopy indicated that L-cells identified by colloidal gold-labeled immunocytochemistry were covered apically with microvilli, open-type and contained many secretory granules in their perikarya. These secretory granules without halo were round to oval in shape and showed moderate electron density. The longest and shortest diameters of secretory granules were 355 +/- 62 nm (mean +/- SD) and 287 +/- 48 nm, respectively. Double labeling immunocytochemistry using two different sizes of particles (6 and 12 nm in diameter) of colloidal gold revealed that GLP-1 colocalized with GLP-2 in the same secretory granules. This study advances new morphological data about the endocrine system of the chicken small intestine. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0916-7250 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10796138 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/23759686/ |
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関連名称 |
23759686 |
権利 |
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権利情報 |
Copyright© 2013 The Japanese Society of Veterinary Science |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000326850900010 |