Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-08-27 |
タイトル |
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タイトル |
Blood-pressure-lowering effect of fermented buckwheat sprouts in spontaneously hypertensive rats |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.jff.2012.11.013 |
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関連名称 |
10.1016/j.jff.2012.11.013 |
キーワード |
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主題 |
Antihypertension, Vasorelaxation, Fermented buckwheat sprouts, Blood pressure |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Nakamura, Kozo
Naramoto, Kyoko
Koyama, Masahiro
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信州大学研究者総覧へのリンク |
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氏名 |
Nakamura, Kozo |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.upyCPUkh.html |
出版者 |
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出版者 |
ELSEVIER SCIENCE BV |
引用 |
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内容記述 |
JOURNAL OF FUNCTIONAL FOODS. 5(1):406-415 (2013) |
書誌情報 |
JOURNAL OF FUNCTIONAL FOODS
巻 5,
号 1,
p. 406-415,
発行日 2013-01
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抄録 |
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内容記述 |
A practical antihypertensive food, neo-fermented buckwheat sprouts (neo-FBS), was produced from buckwheat sprouts by lactic fermentation. The neo-FBS preparation gave a 12.7 times better yield and had a 10 times more potent blood-pressure-lowering (BPL) effect than conventionally prepared products. Neo-FBS decreased both systolic and diastolic blood pressure in spontaneously hypertensive rats (SHRs) at a dose of 0.010 mg/kg, an effect comparable to 1.0 mg/kg captopril, an anti-hypertensive drug. Orally administered neo-FBS (10 mg/kg) significantly decreased angiotensin I-converting enzyme (ACE) activity in the lung, thoracic aorta, heart, kidney, and liver of SHRs. Neo-FBS had a detectable relaxing effect on a phenylephrine-precontracted thoracic aorta in SHRs at 0.5 mu g/mL and the EC50 value was 8.3 +/- 1.4 mu g/mL. The ACE inhibition and vasorelaxation activities were found to be responsible for the excellent BPL effect of neo-FBS. As SHR is a standard model for human hypertension, neo-FBS may also have BPL effects in human patients. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1756-4646 |
権利 |
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権利情報 |
Copyright© 2012 Elsevier Ltd. All rights reserved. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000315241500048 |