Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-01-22 |
タイトル |
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タイトル |
Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.fob.2012.11.002 |
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関連名称 |
10.1016/j.fob.2012.11.002 |
キーワード |
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主題 |
iODN, Class I iODN, Class II iODN, Class I/II hybrid iODN, immunosuppression |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Ito, Yusuke
Shigemori, Suguru
Sato, Takashi
Shimazu, Tomoyuki
Hatano, Konomi
Otani, Hajime
Kitazawa, Haruki
Shimosato, Takeshi
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信州大学研究者総覧へのリンク |
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氏名 |
Shimosato, Takeshi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html |
出版者 |
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出版者 |
ELSEVIER |
引用 |
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内容記述 |
FEBS Open Bio. 3:41-45 (2013) |
書誌情報 |
FEBS Open Bio
巻 3,
p. 41-45,
発行日 2013
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抄録 |
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内容記述 |
We designed class I/II hybrid inhibitory oligodeoxynucleotides (iODNs), called iSG, and found that the sequence 5′-TTAGGG-3′, which has a six-base loop head structure, and a 3′-oligo (dG)3–5 tail sequence are important for potent immunosuppressive activity. Interestingly, splenocytes isolated from ovalbumin (OVA)-immunized mice and treated with iSG3 showed suppression of not only interleukin (IL)-6, IL-12p35, IL-12p40, and interferon (IFN) γ mRNA expression, but also IL-4 and IL-13 mRNA expression. Thus, both Th2 and Th1 immune responses can be strongly suppressed by iODNs in splenocytes from allergen-immunized mice, suggesting usefulness in the treatment of diseases induced by over-active immune activation. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2211-5463 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/23847756/ |
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関連名称 |
23847756 |
権利 |
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権利情報 |
Copyright© 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000339569800008 |