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Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells
http://hdl.handle.net/10091/13195
http://hdl.handle.net/10091/13195a80c1f61-b5e3-4eb1-9771-96066c39f0dc
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2011-06-22 | |||||||
タイトル | ||||||||
タイトル | Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells | |||||||
言語 | ||||||||
言語 | eng | |||||||
DOI | ||||||||
関連識別子 | https://doi.org/10.1111/j.1740-0929.2010.00788.x | |||||||
関連名称 | 10.1111/j.1740-0929.2010.00788.x | |||||||
キーワード | ||||||||
主題 | degranulation, Lactobacillus, mast cell, toll-like receptor 2, type-I allergy | |||||||
資源タイプ | ||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||
タイプ | journal article | |||||||
著者 |
Kawahara, Takeshi
× Kawahara, Takeshi
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信州大学研究者総覧へのリンク | ||||||||
氏名 | Kawahara, Takeshi | |||||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVymPUkh.html | |||||||
出版者 | ||||||||
出版者 | WILEY-BLACKWELL PUBLISHING, INC | |||||||
引用 | ||||||||
内容記述 | ANIMAL SCIENCE JOURNAL. 81(6):714-721 (2010) | |||||||
書誌情報 |
ANIMAL SCIENCE JOURNAL 巻 81, 号 6, p. 714-721, 発行日 2010-12 |
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内容記述 | ||||||||
内容記述 | The definitive version is available at www.blackwell-synergy.com | |||||||
抄録 | ||||||||
内容記述 | This study investigated the in vitro effect of Lactobacillus strains, a major group of probiotic lactic acid bacteria, on immunoglobulin E (IgE)- and antigen-induced mast cell degranulation and subsequent gene expression. Bone marrow-derived mast cells (BMMCs) from DBA/2 mice were cultured with heat-killed Lactobacillus strains for 24 h. Some strains significantly inhibited IgE- and antigen-induced beta-hexosaminidase release from BMMCs. Furthermore, Lactobacillus reuteri NBRC 15892, which exhibited the strongest inhibitory activity, significantly reduced the elevated interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and cyclooxygenase-2 expression levels that was induced by 1-2 h of stimulation with IgE and antigens. The suppressive effect of NBRC 15892 strain on BMMC degranulation was significantly reduced in the presence of a toll-like receptor (TLR)2-neutralizing antibody. In addition, downregulation of cell surface Fc epsilon RI alpha expression was observed after 6 h of NBRC 15892 treatment. These results suggest that some Lactobacillus strains inhibited IgE-mediated mast cell degranulation and subsequent late-phase reactions involving mast cells via a TLR2-dependent mechanism with Fc epsilon RI alpha downregulation. | |||||||
資源タイプ(コンテンツの種類) | ||||||||
内容記述 | Article | |||||||
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収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 1344-3941 | |||||||
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収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA11677214 | |||||||
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出版タイプ | AM | |||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
WoS | ||||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000284643800014 |