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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells

http://hdl.handle.net/10091/13195
a80c1f61-b5e3-4eb1-9771-96066c39f0dc
名前 / ファイル ライセンス アクション
Inhibitory_effect_heat-killed_Lactobacillus_strain.pdf Inhibitory_effect_heat-killed_Lactobacillus_strain.pdf (380.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-06-22
タイトル
言語 en
タイトル Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells
言語
言語 eng
キーワード
主題Scheme Other
主題 degranulation
キーワード
主題Scheme Other
主題 Lactobacillus
キーワード
主題Scheme Other
主題 mast cell
キーワード
主題Scheme Other
主題 toll-like receptor 2
キーワード
主題Scheme Other
主題 type-I allergy
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kawahara, Takeshi

× Kawahara, Takeshi

WEKO 32614

Kawahara, Takeshi

Search repository
信州大学研究者総覧へのリンク
氏名 Kawahara, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVymPUkh.html
出版者
出版者 WILEY-BLACKWELL PUBLISHING, INC
引用
内容記述タイプ Other
内容記述 ANIMAL SCIENCE JOURNAL. 81(6):714-721 (2010)
書誌情報 ANIMAL SCIENCE JOURNAL

巻 81, 号 6, p. 714-721, 発行日 2010-12
内容記述
内容記述タイプ Other
内容記述 The definitive version is available at www.blackwell-synergy.com
抄録
内容記述タイプ Abstract
内容記述 This study investigated the in vitro effect of Lactobacillus strains, a major group of probiotic lactic acid bacteria, on immunoglobulin E (IgE)- and antigen-induced mast cell degranulation and subsequent gene expression. Bone marrow-derived mast cells (BMMCs) from DBA/2 mice were cultured with heat-killed Lactobacillus strains for 24 h. Some strains significantly inhibited IgE- and antigen-induced beta-hexosaminidase release from BMMCs. Furthermore, Lactobacillus reuteri NBRC 15892, which exhibited the strongest inhibitory activity, significantly reduced the elevated interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and cyclooxygenase-2 expression levels that was induced by 1-2 h of stimulation with IgE and antigens. The suppressive effect of NBRC 15892 strain on BMMC degranulation was significantly reduced in the presence of a toll-like receptor (TLR)2-neutralizing antibody. In addition, downregulation of cell surface Fc epsilon RI alpha expression was observed after 6 h of NBRC 15892 treatment. These results suggest that some Lactobacillus strains inhibited IgE-mediated mast cell degranulation and subsequent late-phase reactions involving mast cells via a TLR2-dependent mechanism with Fc epsilon RI alpha downregulation.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1344-3941
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11677214
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1740-0929.2010.00788.x
関連名称
関連名称 10.1111/j.1740-0929.2010.00788.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000284643800014
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