{"_buckets": {"deposit": "9271f25c-f6c4-44a0-a72b-6899cea29122"}, "_deposit": {"id": "10350", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10350"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00010350"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-09-16", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "357", "bibliographicPageStart": "354", "bibliographicVolumeNumber": "64", "bibliographic_titles": [{"bibliographic_title": "MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Five-week-old mice were given a diet consisting of ovalbumin alone (OVA, control diet) or a mixture of OVA, Escherichia coli, and its specific bovine milk IgG (IgG/E.coli added diet) as a protein source for 5 weeks, and mRNAs extracted from Peyer\u0027s patch cells of the mice were analyzed by means of DNA microarray. The gene expression of proteins relating to immunoglobulin production and development of immune diseases was reduced in mice given the IgG/E.coli-added diet compared with those given the control diet. In contrast, the gene expression of marker proteins on Th1, Th3, and negatively regulatory T cells was noticeably increased. On the other hand, Peyer\u0027s patch cells from mice that had not been given any E. coli or milk IgG were cultured with milk IgG, E. coli, or a mixture of E. coli and its specific milk IgG, and were subjected to a cell function analyzer. The numbers of CD19(+) cells and interleukin-4(+)CD4(+) cells increased significantly when the cells were cultured with either milk IgG or E. coli, while the mixture of E coli and its specific milk IgG hardly influenced the numbers of these cells. These results indicate that the result obtained by DNA microarray analysis is not due to free milk IgG or E. coli alone, but is attributable to a mixture of E. coli and its specific IgG, suggesting that a mixture of E. coli and its specific IgG in intestinal tracts would reduce the development of allergic symptoms and autoimmune diseases.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 64(4):354-357 (2009)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000270072200002"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "A V A AGRARVERLAG"}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0026-3788", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0026-3788", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00285427", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Allergies (modulation in mice); autoimmune diseases (modulation in mice)"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "RHEUMATOID-ARTHRITIS; IMMUNOGLOBULIN-G; T-CELLS; MECHANISM; MOUSE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Five-week-old mice were given a diet consisting of ovalbumin alone (OVA, control diet) or a mixture of OVA, Escherichia coli, and its specific bovine milk IgG (IgG/E.coli added diet) as a protein source for 5 weeks, and mRNAs extracted from Peyer\u0027s patch cells of the mice were analyzed by means of DNA microarray. The gene expression of proteins relating to immunoglobulin production and development of immune diseases was reduced in mice given the IgG/E.coli-added diet compared with those given the control diet. In contrast, the gene expression of marker proteins on Th1, Th3, and negatively regulatory T cells was noticeably increased. On the other hand, Peyer\u0027s patch cells from mice that had not been given any E. coli or milk IgG were cultured with milk IgG, E. coli, or a mixture of E. coli and its specific milk IgG, and were subjected to a cell function analyzer. The numbers of CD19(+) cells and interleukin-4(+)CD4(+) cells increased significantly when the cells were cultured with either milk IgG or E. coli, while the mixture of E coli and its specific milk IgG hardly influenced the numbers of these cells. 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