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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Microarray analysis of mRNAs extracted from the Peyer's patch cells of mice given a diet including Escherichia coli and its specific bovine milk IgG

http://hdl.handle.net/10091/10766
323fea40-832e-4dd3-a411-9bce7cd4160f
名前 / ファイル ライセンス アクション
microarray_analysis_mRNAs_extracte.pdf microarray_analysis_mRNAs_extracte.pdf (4.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-11-15
タイトル
言語 en
タイトル Microarray analysis of mRNAs extracted from the Peyer's patch cells of mice given a diet including Escherichia coli and its specific bovine milk IgG
言語
言語 eng
キーワード
主題Scheme Other
主題 Allergies (modulation in mice)
キーワード
主題Scheme Other
主題 autoimmune diseases (modulation in mice)
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sueda, Yu

× Sueda, Yu

WEKO 32751

Sueda, Yu

Search repository
Otani, Hajime

× Otani, Hajime

WEKO 32752

Otani, Hajime

Search repository
出版者
出版者 A V A AGRARVERLAG
引用
内容記述タイプ Other
内容記述 MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL. 64(4):354-357 (2009)
書誌情報 MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL

巻 64, 号 4, p. 354-357, 発行日 2009-09-16
抄録
内容記述タイプ Abstract
内容記述 Five-week-old mice were given a diet consisting of ovalbumin alone (OVA, control diet) or a mixture of OVA, Escherichia coli, and its specific bovine milk IgG (IgG/E.coli added diet) as a protein source for 5 weeks, and mRNAs extracted from Peyer's patch cells of the mice were analyzed by means of DNA microarray. The gene expression of proteins relating to immunoglobulin production and development of immune diseases was reduced in mice given the IgG/E.coli-added diet compared with those given the control diet. In contrast, the gene expression of marker proteins on Th1, Th3, and negatively regulatory T cells was noticeably increased. On the other hand, Peyer's patch cells from mice that had not been given any E. coli or milk IgG were cultured with milk IgG, E. coli, or a mixture of E. coli and its specific milk IgG, and were subjected to a cell function analyzer. The numbers of CD19(+) cells and interleukin-4(+)CD4(+) cells increased significantly when the cells were cultured with either milk IgG or E. coli, while the mixture of E coli and its specific milk IgG hardly influenced the numbers of these cells. These results indicate that the result obtained by DNA microarray analysis is not due to free milk IgG or E. coli alone, but is attributable to a mixture of E. coli and its specific IgG, suggesting that a mixture of E. coli and its specific IgG in intestinal tracts would reduce the development of allergic symptoms and autoimmune diseases.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0026-3788
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00285427
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270072200002
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