{"_buckets": {"deposit": "7c47a905-7ae5-4f3a-85c7-d1f64c6952ed"}, "_deposit": {"id": "10423", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10423"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00010423", "sets": ["1017"]}, "author_link": ["32972", "32973", "32974"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "1322", "bibliographicPageStart": "1315", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "International immunopharmacology"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "INTERNATIONAL IMMUNOPHARMACOLOGY. 6(8): 1315-1322 (2006)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000238874100013"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ELSEVIER SCIENCE BV"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.intimp.2006.04.006"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.intimp.2006.04.006", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1567-5769", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1567-5769", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11516496", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "cow\u0027s milk IgG; macrophages; natural killer cells; CD4(+) cells; antibody responses"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "REGULATORY T-CELLS; IMMUNOLOGICAL SELF-TOLERANCE; DENDRITIC CELLS; CUTTING EDGE; IGG; ANTIBODY; MICE; MACROPHAGES; INTEGRIN"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Four-week-old male C3H/HeN mice were bred with diets consisting of ovalbumin alone (OVA, control diet) or mixtures of OVA and cow\u0027s milk immunoglobulin G (IgG-added diets) as a protein source for 4 or 5 weeks, and both the cellular and humoral immune properties of the mice were investigated. The number of interleukin (IL)-12(+)CD11b(+) cells in spleens and the formation of superoxide by peritoneal macrophages were higher in mice given the IgG-added diet than in those given the control diet. The number of natural killer cells in Peyer\u0027s patches or spleens and the cytotoxic activity of spleen cells toward an erythroleukemia cell line. K562, were also higher in mice given the IgG-added diet. In contrast, the numbers of interferon-gamma(+)CD4(+) and IL-4(+)CD4(+) cells in Peyer\u0027s patches or spleens and the levels of total or OVA-specific intestinal IgA and serum lgG were significantly lower in mice given the IgG-added diet than in those given the control diet. In addition, the number of cells expressing CD19 in spleens was significantly higher in mice given the IgG-added diet. These results indicate that oral ingestion of cow\u0027s milk IgG may stimulate some innate cellular immune systems, while suppressing humoral adaptive immune responses in the mouse. (c) 2006 Elsevier B.V. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohnuki,  H"}], "nameIdentifiers": [{"nameIdentifier": "32972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizutani,  A"}], "nameIdentifiers": [{"nameIdentifier": "32973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Otani,  H"}], "nameIdentifiers": [{"nameIdentifier": "32974", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "International Immunopharmacologytex.pdf", "filesize": [{"value": "237.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 237700.0, "url": {"label": "International Immunopharmacologytex.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/10423/files/International Immunopharmacologytex.pdf"}, "version_id": "4076315f-b64d-4efa-9124-66634313650a"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Oral ingestion of cow\u0027s milk immunoglobulin G stimulates some cellular immune systems and suppresses humoral immune responses in mouse", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Oral ingestion of cow\u0027s milk immunoglobulin G stimulates some cellular immune systems and suppresses humoral immune responses in mouse", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1017"], "permalink_uri": "http://hdl.handle.net/10091/570", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-11-20"}, "publish_date": "2007-11-20", "publish_status": "0", "recid": "10423", "relation": {}, "relation_version_is_last": true, "title": ["Oral ingestion of cow\u0027s milk immunoglobulin G stimulates some cellular immune systems and suppresses humoral immune responses in mouse"], "weko_shared_id": -1}