WEKO3
アイテム
{"_buckets": {"deposit": "c8d5f660-5f4a-4d3c-938e-46c69a5a82fe"}, "_deposit": {"id": "10436", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10436"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00010436", "sets": ["1017"]}, "author_link": ["33029", "33030", "33031", "33032"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "615", "bibliographicPageStart": "610", "bibliographicVolumeNumber": "33", "bibliographic_titles": [{"bibliographic_title": "Journal of industrial microbiology \u0026 biotechnology"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The original publication is available at www.springerlink.com.", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Journal of Industrial Microbiology \u0026 Biotechnology. 33(7): 610-615 (2006)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Ikeda, M", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uhLNPUkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000239443800018"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER HEIDELBERG"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "16506038"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/16506038/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s10295-006-0104-5"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s10295-006-0104-5", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1367-5435", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1367-5435", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11132053", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "amino acid fermentation; metabolic engineering; classical mutagenesis; genomics; L-lysine; Corynebacterium glutamicum"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "AMINO-ACIDS; MUTANT"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Based on the progress in genomics, we have developed a novel approach that employs genomic information to generate an efficient amino acid producer. A comparative genomic analysis of an industrial L-lysine producer with its natural ancestor identified a variety of mutations in genes associated with L-lysine biosynthesis. Among these mutations, we identified two mutations in the relevant terminal pathways as key mutations for L-lysine production, and three mutations in central metabolism that resulted in increased titers. These five mutations when assembled in the wild-type genome led to a significant increase in both the rate of production and final L-lysine titer. Further investigations incorporated with transcriptome analysis suggested that other as yet unidentified mutations are necessary to support the L-lysine titers observed by the original production strain. Here we describe the essence of our approach for strain reconstruction, and also discuss mechanisms Of L-lysine hyperproduction unraveled by combining genomics with classical strain improvement."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ikeda, M"}], "nameIdentifiers": [{"nameIdentifier": "33029", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohnishi, J"}], "nameIdentifiers": [{"nameIdentifier": "33030", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, M"}], "nameIdentifiers": [{"nameIdentifier": "33031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mitsuhashi, S"}], "nameIdentifiers": [{"nameIdentifier": "33032", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "A genome-based approach.pdf", "filesize": [{"value": "413.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 413200.0, "url": {"label": "A genome-based approach.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/10436/files/A genome-based approach.pdf"}, "version_id": "e742c9b7-8898-4607-b413-f77ff349e974"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A genome-based approach to create a minimally mutated, Corynebacterium glutamicm strain for efficient L-lysine production", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A genome-based approach to create a minimally mutated, Corynebacterium glutamicm strain for efficient L-lysine production", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1017"], "permalink_uri": "http://hdl.handle.net/10091/198", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-05-07"}, "publish_date": "2007-05-07", "publish_status": "0", "recid": "10436", "relation": {}, "relation_version_is_last": true, "title": ["A genome-based approach to create a minimally mutated, Corynebacterium glutamicm strain for efficient L-lysine production"], "weko_shared_id": -1}
A genome-based approach to create a minimally mutated, Corynebacterium glutamicm strain for efficient L-lysine production
http://hdl.handle.net/10091/198
http://hdl.handle.net/10091/1981dfb0542-881d-4f13-a1a5-5d930b2553ba
名前 / ファイル | ライセンス | アクション |
---|---|---|
A genome-based approach.pdf (413.2 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-05-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A genome-based approach to create a minimally mutated, Corynebacterium glutamicm strain for efficient L-lysine production | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10295-006-0104-5 | |||||
関連名称 | 10.1007/s10295-006-0104-5 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ikeda, M
× Ikeda, M× Ohnishi, J× Hayashi, M× Mitsuhashi, S |
|||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ikeda, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uhLNPUkh.html | |||||
出版者 | ||||||
出版者 | SPRINGER HEIDELBERG | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Industrial Microbiology & Biotechnology. 33(7): 610-615 (2006) | |||||
書誌情報 |
Journal of industrial microbiology & biotechnology 巻 33, 号 7, p. 610-615, 発行日 2006-07 |
|||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1367-5435 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11132053 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/16506038/ | |||||
関連名称 | 16506038 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000239443800018 |