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We showed that the vinegar has tumor-suppressing effect in vivo (mice)and apoptosis-inducing activity in vitro (U937 cells)analysis. We also isolated tryptophol as an apoptosis-inducing component from the vinegar and examined its apoptosis-inducing mechanisms in U937 cells. Caspase activity determination and western blot analysis revealed that tryptophol activated caspase-8 and -3. Immunoprecipitation analysis also revealed that tryptophol induced binding of caspase-8 and death receptor (DR)5. From these analyses, tryptophol was supposed to induce apoptosis via DR5, caspase-8 and caspase-3. Furthermore we comfirmed that tryptophol was produced from tryptophan in raw material by Saccharomyces cerevisiae kyokai no. 77 in the process of ethanol fermentation. 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