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A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse
http://hdl.handle.net/10091/15965
http://hdl.handle.net/10091/15965584cee8a-f50e-43a1-8a98-e0639903c334
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Single_Amino_Acid_Mutation_SNAP-25.pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-09-11 | |||||
| タイトル | ||||||
| タイトル | A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0025158 | |||||
| 関連名称 | 10.1371/journal.pone.0025158 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PROTEIN-KINASE-C | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ACTIVITY-DEPENDENT PHOSPHORYLATION | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | SYNAPTOSOME-ASSOCIATED PROTEIN | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NEUROTRANSMITTER RELEASE | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PHORBOL ESTER | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MEMBRANE-FUSION | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PC12 CELLS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RAT-BRAIN | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | EXOCYTOSIS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ENHANCEMENT | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kataoka, Masakazu
× Kataoka, Masakazu× Yamamori, Saori× Suzuki, Eiji× Watanabe, Shigeru× Sato, Taku× Miyaoka, Hitoshi× Azuma, Sadahiro× Ikegami, Shiro× Kuwahara, Reiko× Suzuki-Migishima, Rika× Nakahara, Yohko× Nihonmatsu, Itsuko× Inokuchi, Kaoru× Katoh-Fukui, Yuko× Yokoyama, Minesuke× Takahashi, Masami |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kataoka, Masakazu | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkebpkh.html | |||||
| 出版者 | ||||||
| 出版者 | PUBLIC LIBRARY SCIENCE | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PLOS ONE. 6(9):e25158 (2011) | |||||
| 書誌情報 |
PLOS ONE 巻 6, 号 9, 発行日 2011-09-20 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Synaptosomal-associated protein of 25 kDa (SNAP-25) is a presynaptic protein essential for neurotransmitter release. Previously, we demonstrate that protein kinase C (PKC) phosphorylates Ser(187) of SNAP-25, and enhances neurotransmitter release by recruiting secretory vesicles near to the plasma membrane. As PKC is abundant in the brain and SNAP-25 is essential for synaptic transmission, SNAP-25 phosphorylation is likely to play a crucial role in the central nervous system. We therefore generated a mutant mouse, substituting Ser(187) of SNAP-25 with Ala using "knock-in" technology. The most striking effect of the mutation was observed in their behavior. The homozygous mutant mice froze readily in response to environmental change, and showed strong anxiety-related behavior in general activity and light and dark preference tests. In addition, the mutant mice sometimes exhibited spontaneously occurring convulsive seizures. Microdialysis measurements revealed that serotonin and dopamine release were markedly reduced in amygdala. These results clearly indicate that PKC-dependent SNAP-25 phosphorylation plays a critical role in the regulation of emotional behavior as well as the suppression of epileptic seizures, and the lack of enhancement of monoamine release is one of the possible mechanisms underlying these defects. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1932-6203 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21949876 | |||||
| 関連名称 | 21949876 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2011 Kataoka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000295260400052 | |||||
