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All mice survived, and no large changes in their weights were observed within our experimental period. After 1 week, only single-walled carbon nanotubes (SWNTs) activated major histocompatibility complex (MHC) class I pathway of antigen-antibody response system (higher CD4(+)/CD8(+) value), resulting in the appearance of an edematous aspect. After 2 weeks, significantly high values in CD4(+) and CD4(+)/CD8(+) without change in CD8(+) signified an activated MHC class II for all samples. It is worth noting that the toxicological response of CNTs was absolutely lower than that of asbestos. As a result, we envisaged that our result (relatively low toxicity of CNTs) will spur the mass-production, as well widespread application of CNTs in the near future. (c) 2005 Elsevier Ltd. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Koyama,  S"}], "nameIdentifiers": [{"nameIdentifier": "39182", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo,  M"}], "nameIdentifiers": [{"nameIdentifier": "39183", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kim,  YA"}], "nameIdentifiers": [{"nameIdentifier": "39184", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi,  T"}], "nameIdentifiers": [{"nameIdentifier": "39185", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagisawa,  T"}], "nameIdentifiers": [{"nameIdentifier": "39186", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Osaka,  K"}], "nameIdentifiers": [{"nameIdentifier": "39187", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama,  H"}], "nameIdentifiers": [{"nameIdentifier": "39188", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroiwa,  N"}], "nameIdentifiers": [{"nameIdentifier": "39189", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "No_8_Carbon_2006.pdf", "filesize": [{"value": "267.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 267700.0, "url": {"label": "No_8_Carbon_2006.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/12736/files/No_8_Carbon_2006.pdf"}, "version_id": "c6f06038-e19d-4c6c-897a-82eb5eef1738"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice"}]}, "item_type_id": "6", "owner": "1", "path": ["1221/1222"], "permalink_uri": "http://hdl.handle.net/10091/98", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2007-02-19"}, "publish_date": "2007-02-19", "publish_status": "0", "recid": "12736", "relation": {}, "relation_version_is_last": true, "title": ["Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice"], "weko_shared_id": null}