Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-08-25 |
タイトル |
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タイトル |
Fabrication and biocompatibility of electrospun silk biocomposites |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.3390/membranes1040275 |
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関連名称 |
10.3390/membranes1040275 |
キーワード |
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主題 |
silk, nanofiber, fibroblast, tetramethoxysilane, hydroxyapatite, osteoblast |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Wei, Kai
Kim, Byoung-Suhk
Kim, Ick-Soo
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信州大学研究者総覧へのリンク |
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氏名 |
Kim, Ick-Soo |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html |
出版者 |
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出版者 |
MDPI |
引用 |
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内容記述 |
Membranes. 1:275-298 (2011) |
書誌情報 |
Membranes
巻 1,
p. 275-298,
発行日 2011
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抄録 |
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内容記述 |
Silk fibroin has attracted great interest in tissue engineering because of its outstanding biocompatibility, biodegradability and minimal inflammatory reaction. In this study, two kinds of biocomposites based on regenerated silk fibroin are fabricated by electrospinning and post-treatment processes, respectively. Firstly, regenerated silk fibroin/tetramethoxysilane (TMOS) hybrid nanofibers with high hydrophilicity are prepared, which is superior for fibroblast attachment. The electrospinning process causes adjacent fibers to 'weld' at contact points, which can be proved by scanning electron microscope (SEM). The water contact angle of silk/tetramethoxysilane (TMOS) composites shows a sharper decrease than pure regenerated silk fibroin nanofiber, which has a great effect on the early stage of cell attachment behavior. Secondly, a novel tissue engineering scaffold material based on electrospun silk fibroin/nano-hydroxyapatite (nHA) biocomposites is prepared by means of an effective calcium and phosphate (Ca-P) alternate soaking method. nHA is successfully produced on regenerated silk fibroin nanofiber within several min without any pre-treatments. The osteoblastic activities of this novel nanofibrous biocomposites are also investigated by employing osteoblastic-like MC3T3-E1 cell line. The cell functionality such as alkaline phosphatase (ALP) activity is ameliorated on mineralized silk nanofibers. All these results indicate that this silk/nHA biocomposite scaffold material may be a promising biomaterial for bone tissue engineering. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2077-0375 |
PubMed |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=24957869 |
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関連名称 |
24957869 |
権利 |
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権利情報 |
Copyright© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |