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  1. 080 繊維学部
  2. 0801 学術論文

Fabrication and biocompatibility of electrospun silk biocomposites

http://hdl.handle.net/10091/17826
c21bebfd-27f7-4ddf-a653-cf14424efa69
名前 / ファイル ライセンス アクション
098_Fabrication_biocompatibility_electrospun_silk_biocomposites.pdf 098_Fabrication_biocompatibility_electrospun_silk_biocomposites.pdf (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-08-25
タイトル
言語 en
タイトル Fabrication and biocompatibility of electrospun silk biocomposites
言語
言語 eng
キーワード
主題Scheme Other
主題 silk
キーワード
主題Scheme Other
主題 nanofiber
キーワード
主題Scheme Other
主題 fibroblast
キーワード
主題Scheme Other
主題 tetramethoxysilane
キーワード
主題Scheme Other
主題 hydroxyapatite
キーワード
主題Scheme Other
主題 osteoblast
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Wei, Kai

× Wei, Kai

WEKO 40316

Wei, Kai

Search repository
Kim, Byoung-Suhk

× Kim, Byoung-Suhk

WEKO 40317

Kim, Byoung-Suhk

Search repository
Kim, Ick-Soo

× Kim, Ick-Soo

WEKO 40318

Kim, Ick-Soo

Search repository
信州大学研究者総覧へのリンク
氏名 Kim, Ick-Soo
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html
出版者
出版者 MDPI
引用
内容記述タイプ Other
内容記述 Membranes. 1:275-298 (2011)
書誌情報 Membranes

巻 1, p. 275-298, 発行日 2011
抄録
内容記述タイプ Abstract
内容記述 Silk fibroin has attracted great interest in tissue engineering because of its outstanding biocompatibility, biodegradability and minimal inflammatory reaction. In this study, two kinds of biocomposites based on regenerated silk fibroin are fabricated by electrospinning and post-treatment processes, respectively. Firstly, regenerated silk fibroin/tetramethoxysilane (TMOS) hybrid nanofibers with high hydrophilicity are prepared, which is superior for fibroblast attachment. The electrospinning process causes adjacent fibers to 'weld' at contact points, which can be proved by scanning electron microscope (SEM). The water contact angle of silk/tetramethoxysilane (TMOS) composites shows a sharper decrease than pure regenerated silk fibroin nanofiber, which has a great effect on the early stage of cell attachment behavior. Secondly, a novel tissue engineering scaffold material based on electrospun silk fibroin/nano-hydroxyapatite (nHA) biocomposites is prepared by means of an effective calcium and phosphate (Ca-P) alternate soaking method. nHA is successfully produced on regenerated silk fibroin nanofiber within several min without any pre-treatments. The osteoblastic activities of this novel nanofibrous biocomposites are also investigated by employing osteoblastic-like MC3T3-E1 cell line. The cell functionality such as alkaline phosphatase (ALP) activity is ameliorated on mineralized silk nanofibers. All these results indicate that this silk/nHA biocomposite scaffold material may be a promising biomaterial for bone tissue engineering.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 2077-0375
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=24957869
関連名称
関連名称 24957869
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/membranes1040275
関連名称
関連名称 10.3390/membranes1040275
権利
権利情報 Copyright© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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