Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-01-18 |
タイトル |
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タイトル |
Identification of a cis-regulatory element that directs prothoracicotropic hormone gene expression in the silkworm Bombyx mori |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.ibmb.2011.02.002 |
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関連名称 |
10.1016/j.ibmb.2011.02.002 |
キーワード |
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主題 |
Neurosecretory cell, Cis-regulatory element, PTTH, DH-PBAN, Pitx, Insect |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Ohtsuka, Kazunori
Atsumi, Tsutomu
Fukushima, Yoshihisa
Shiomi, Kunihiro
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信州大学研究者総覧へのリンク |
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氏名 |
Shiomi, Kunihiro |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WCnpjFkV.html |
出版者 |
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出版者 |
PERGAMON-ELSEVIER SCIENCE LTD |
引用 |
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内容記述 |
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY. 41(6):356-361 (2011) |
書誌情報 |
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
巻 41,
号 6,
p. 356-361,
発行日 2011-06
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抄録 |
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内容記述 |
In the silkworm Bombyx mori and other insects, prothoracicotropic hormone (PITH) plays a central role in controlling molting and metamorphosis by stimulating the prothoracic glands to synthesize and release the molting hormone ecdysone. Using an AcNPV (Autographa californica nucleopolyhedrovirus)mediated transient gene transfer system, we identified a cis-regulatory element that participates in the decision to switch expression of PTTH on or off in PTTH-producing neurosecretory cells (PTPCs). The nucleotide sequence of this cis-regulatory element is similar to a cis-regulatory element that participates in direction of expression of diapause hormone-pheromone biosynthesis activating neuropeptide gene (DH-PBAN) (Shiomi et al., 2007). Furthermore, we found that B. mori Pitx (BmPitx), a bicoid-like homeobox transcription factor, binds the element and activates PITH expression. Therefore, we propose that the cell-specific expression of two neuropeptide hormone genes, PITH and DH-PBAN, is activated by the Pitx transcription factor, which may act as a pan-activator in the insect neuroendocrine system and in vertebrate pituitary cells. (C) 2011 Elsevier Ltd. All rights reserved. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0965-1748 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10828030 |
PubMed |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21324358 |
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関連名称 |
21324358 |
権利 |
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権利情報 |
Copyright© 2011 Elsevier Ltd. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000290355300002 |