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A rapid and convenient protein extraction method (Shindai method) and novel procedures for preparing their protein films from their extracts have been developed using human hair and nail. The effects of the human hair and nail proteins and their films on histamine release from rat peritoneal mast cells were investigated. Both protein solutions and their films, mainly consisting of keratins and matrix proteins, did not induce histamine release from the mast cells. Scanning electron microscopy (SEM) also showed that the mast cells were only slightly affected by adding the human hair and nail proteins or by incubating on their protein films. The IgE-dependent histamine release was inhibited by the hair and nail proteins and their films. Incubation of the mast cells with the hair and nail proteins prior to the addition of the IgE serum resulted in a high inhibition (50%) of the histamine release, while the inhibition was approximately 10% when the protein solutions were mixed with the mast cells after incubation with the IgE serum. These results suggest that the human hair and nail proteins and their films will be useful materials for antiallergic actions."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujii, T"}], "nameIdentifiers": [{"nameIdentifier": "41358", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murai, S"}], "nameIdentifiers": [{"nameIdentifier": "41359", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohkawa, K"}], "nameIdentifiers": [{"nameIdentifier": "41360", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirai, T"}], "nameIdentifiers": [{"nameIdentifier": "41361", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Effects of human hair.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "Effects of human hair.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/13527/files/Effects of human hair.pdf"}, "version_id": "078d8290-3b6c-43f9-8fb3-391a5abcea95"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of human hair and nail proteins and their films on rat mast cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of human hair and nail proteins and their films on rat mast cells", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1310"], "permalink_uri": "http://hdl.handle.net/10091/1096", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-06-26"}, "publish_date": "2008-06-26", "publish_status": "0", "recid": "13527", "relation": {}, "relation_version_is_last": true, "title": ["Effects of human hair and nail proteins and their films on rat mast cells"], "weko_shared_id": -1}
Effects of human hair and nail proteins and their films on rat mast cells
http://hdl.handle.net/10091/1096
http://hdl.handle.net/10091/1096ba294a2a-e049-43c9-9c7d-8a7aa1d3c498
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-06-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of human hair and nail proteins and their films on rat mast cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Fujii, T
× Fujii, T× Murai, S× Ohkawa, K× Hirai, T |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Fujii, T | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WVyFjekV.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ohkawa, K | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gUfejekV.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Hirai, T | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WFyCjekV.html | |||||
出版者 | ||||||
出版者 | SPRINGER | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 19(6): 2335-2342 (2008) | |||||
書誌情報 |
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 巻 19, 号 6, p. 2335-2342, 発行日 2008-06 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0957-4530 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10761712 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10856-007-3341-x | |||||
関連名称 | 10.1007/s10856-007-3341-x | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000254624600013 |