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  1. 080 繊維学部
  2. 0801 学術論文

Rescue of Vitrified-Warmed Bovine Oocytes with Rho-Associated Coiled-Coil Kinase Inhibitor

http://hdl.handle.net/10091/00018690
5eafedf2-2798-4436-9426-366022efc651
名前 / ファイル ライセンス アクション
Rescue_of_Vitrified-Warmed_Bovine_Oocytes.pdf Rescue_of_Vitrified-Warmed_Bovine_Oocytes.pdf (489.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-03-23
タイトル
言語 en
タイトル Rescue of Vitrified-Warmed Bovine Oocytes with Rho-Associated Coiled-Coil Kinase Inhibitor
言語
言語 eng
キーワード
主題Scheme Other
主題 apoptosis
キーワード
主題Scheme Other
主題 bovine oocytes
キーワード
主題Scheme Other
主題 cryopreservation
キーワード
主題Scheme Other
主題 Cryotop vitrification
キーワード
主題Scheme Other
主題 cytoskeleton
キーワード
主題Scheme Other
主題 microtubule assembly
キーワード
主題Scheme Other
主題 oocyte
キーワード
主題Scheme Other
主題 ROCK inhibitor
キーワード
主題Scheme Other
主題 vitrification
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Hwang, In-Sul

× Hwang, In-Sul

WEKO 50053

Hwang, In-Sul

Search repository
Hara, Hiromasa

× Hara, Hiromasa

WEKO 50054

Hara, Hiromasa

Search repository
Chung, Hak-Jae

× Chung, Hak-Jae

WEKO 50055

Chung, Hak-Jae

Search repository
Hirabayashi, Masumi

× Hirabayashi, Masumi

WEKO 50056

Hirabayashi, Masumi

Search repository
Hochi, Shinichi

× Hochi, Shinichi

WEKO 50057

Hochi, Shinichi

Search repository
信州大学研究者総覧へのリンク
氏名 Hochi, S
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HhfNjekV.html
出版者
出版者 SOC STUDY REPRODUCTION
引用
内容記述タイプ Other
内容記述 BIOLOGY OF REPRODUCTION. 89(2):26 (2013)
書誌情報 BIOLOGY OF REPRODUCTION

巻 89, 号 2, p. 26, 発行日 2013-08
抄録
内容記述タイプ Abstract
内容記述 Cryotolerance of matured bovine oocytes is not fully practical even though a promising vitrification procedure with a ultrarapid cooling rate was applied. The present study was conducted to investigate whether recovery culture of vitrified-warmed bovine oocytes with an inhibitor (Y-27632) of Rho-associated coiled-coil kinase (ROCK) can improve the developmental potential after in vitro fertilization (IVF) and in vitro culture. Immediately after warming, almost all oocytes appeared to be morphological normal. Treatment of the postwarming oocytes with 10 μM Y-27632 for 2 h resulted in the significantly higher oocyte survival rate before IVF as well as higher cleavage rate and blastocyst formation rate. Quality analysis of the resultant blastocysts in terms of total cell number and apoptotic cell ratio also showed the positive effect of the Y-27632 treatment. Time-dependent change in mitochondrial activity of the vitrified-warmed oocytes was not influenced by ROCK inhibition during the period of recovery culture. However, the ability of ooplasm to support single-aster formation was improved by the ROCK inhibition. Thus, inhibition of ROCK activity in vitrified-warmed bovine oocytes during a short-term recovery culture can lead to higher developmental competence, probably due to decreased apoptosis and normalized function of the microtubule-organizing center.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-3363
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00565842
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=23782835
関連名称
関連名称 23782835
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1095/biolreprod.113.109769
関連名称
関連名称 10.1095/biolreprod.113.109769
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000323165800004
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