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Inhibitory Effect of a Hot-Water Extract of Leaves of Japanese Big-Leaf Magnolia (Magnolia obovata) on Rotavirus-Induced Diarrhea in Mouse Pups
http://hdl.handle.net/10091/00018786
http://hdl.handle.net/10091/0001878658c82e79-dbef-43b8-8bd8-2a01fc764fa0
名前 / ファイル | ライセンス | アクション |
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Inhibitory_Effect_Hot-Water_Extract_Leaves.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-04-22 | |||||
タイトル | ||||||
タイトル | Inhibitory Effect of a Hot-Water Extract of Leaves of Japanese Big-Leaf Magnolia (Magnolia obovata) on Rotavirus-Induced Diarrhea in Mouse Pups | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1155/2014/365831 | |||||
関連名称 | 10.1155/2014/365831 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawahara, Takeshi
× Kawahara, Takeshi× Tomono, Takuma× Hamauzu, Yasunori× Tanaka, Katsumi× Yasui, Hisako |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Kawahara, Takeshi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVymPUkh.html | |||||
出版者 | ||||||
出版者 | HINDAWI PUBLISHING CORPORATION | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2014:365831 (2014) | |||||
書誌情報 |
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 巻 2014, 発行日 2014-01 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The leaf of Japanese big-leaf magnolia (Magnolia obovata Thunb.) has long been used as a natural packaging material for traditional foods in Japan. However, many of the physiological functions of the leaves against oral infection and resultant illness remain unclear. The aim of the present study was to investigate the effects of a hot-water extract of the leaves of Magnolia obovata on diarrhea induced by rotavirus (RV), a major cause of acute diarrhea. RV strain SA11 was mixed with the M. obovata leaf extract and inoculated orally to neonatal BALB/c mouse pups. Simultaneous inoculation of SA11 with the extract significantly decreased the incidence of diarrhea. In addition, the extract significantly inhibited cytopathic effects and mRNA expression of viral proteins in SA11-infected MA104 cells. Two flavonoid glycosides, quercitrin and rutin, were strongly suggested to be major anti-RV agents in the extract by serial solvent extraction and reversed-phase HPLC-ESI-MS analysis. Our results suggest that the hot-water extract of M. obovata leaves can be used as a medicine or food additive to prevent and ameliorate RV-induced diarrhea in individuals that may have difficulty in benefitting from the RV vaccines. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741-427X | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11968793 | |||||
権利 | ||||||
権利情報 | Copyright © 2014 Takeshi Kawahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
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表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000347001400001 |