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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Inhibitory Effect of a Hot-Water Extract of Leaves of Japanese Big-Leaf Magnolia (Magnolia obovata) on Rotavirus-Induced Diarrhea in Mouse Pups

http://hdl.handle.net/10091/00018786
58c82e79-dbef-43b8-8bd8-2a01fc764fa0
名前 / ファイル ライセンス アクション
Inhibitory_Effect_Hot-Water_Extract_Leaves.pdf Inhibitory_Effect_Hot-Water_Extract_Leaves.pdf (2.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-04-22
タイトル
言語 en
タイトル Inhibitory Effect of a Hot-Water Extract of Leaves of Japanese Big-Leaf Magnolia (Magnolia obovata) on Rotavirus-Induced Diarrhea in Mouse Pups
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kawahara, Takeshi

× Kawahara, Takeshi

WEKO 50391

Kawahara, Takeshi

Search repository
Tomono, Takuma

× Tomono, Takuma

WEKO 50392

Tomono, Takuma

Search repository
Hamauzu, Yasunori

× Hamauzu, Yasunori

WEKO 50393

Hamauzu, Yasunori

Search repository
Tanaka, Katsumi

× Tanaka, Katsumi

WEKO 50394

Tanaka, Katsumi

Search repository
Yasui, Hisako

× Yasui, Hisako

WEKO 50395

Yasui, Hisako

Search repository
信州大学研究者総覧へのリンク
氏名 Kawahara, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVymPUkh.html
出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述タイプ Other
内容記述 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2014:365831 (2014)
書誌情報 EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

巻 2014, 発行日 2014-01
抄録
内容記述タイプ Abstract
内容記述 The leaf of Japanese big-leaf magnolia (Magnolia obovata Thunb.) has long been used as a natural packaging material for traditional foods in Japan. However, many of the physiological functions of the leaves against oral infection and resultant illness remain unclear. The aim of the present study was to investigate the effects of a hot-water extract of the leaves of Magnolia obovata on diarrhea induced by rotavirus (RV), a major cause of acute diarrhea. RV strain SA11 was mixed with the M. obovata leaf extract and inoculated orally to neonatal BALB/c mouse pups. Simultaneous inoculation of SA11 with the extract significantly decreased the incidence of diarrhea. In addition, the extract significantly inhibited cytopathic effects and mRNA expression of viral proteins in SA11-infected MA104 cells. Two flavonoid glycosides, quercitrin and rutin, were strongly suggested to be major anti-RV agents in the extract by serial solvent extraction and reversed-phase HPLC-ESI-MS analysis. Our results suggest that the hot-water extract of M. obovata leaves can be used as a medicine or food additive to prevent and ameliorate RV-induced diarrhea in individuals that may have difficulty in benefitting from the RV vaccines.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1741-427X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11968793
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2014/365831
関連名称
関連名称 10.1155/2014/365831
権利
権利情報 Copyright © 2014 Takeshi Kawahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000347001400001
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