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Activation of PPAR\u03b1 by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis\uff08\u8102\u80aa\u9178\u84c4\u7a4d\u306b\u3088\u308bPPAR\u03b1\u6d3b\u6027\u5316\u306f\u8102\u80aa\u9178\u5206\u89e3\u3068\u30b9\u30eb\u30d5\u30a1\u30c1\u30c9\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\uff09. \u4fe1\u5dde\u5927\u5b66, 2016, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1064\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000386641700003"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27644403"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=27644403", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1620/tjem.240.113"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1620/tjem.240.113", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2016 Tohoku University Medical Press"}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1064\u53f7"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ACYL-COA DEHYDROGENASE; COENZYME-A DEHYDROGENASE; RAT-LIVER; CEREBROSIDE SULFOTRANSFERASE; DISTINCT SPECIFICITIES; MUTATION ANALYSIS; RECEPTORS ALPHA; GENE-EXPRESSION; DEFICIENCY; METABOLISM"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes the first reaction in the mitochondrial fatty acid beta-oxidation pathway. VLCAD deficiency is associated with the accumulation of fat in multiple organs and tissues, which results in specific clinical features including cardiomyopathy, cardiomegaly, muscle weakness, and hepatic dysfunction in infants. We speculated that the abnormal fatty acid metabolism in VLCAD-deficient individuals might cause cell necrosis by fatty acid toxicity. The accumulation of fatty acids may activate peroxisome proliferator-activated receptor (PPAR), a master regulator of fatty acid metabolism and a potent nuclear receptor for free fatty acids. We examined six skin fibroblast lines, derived from VLCAD-deficient patients and identified fatty acid accumulation and PPAR alpha activation in these cell lines. We then found that the expression levels of three enzymes involved in fatty acid degradation, including long-chain acyl-CoA synthetase (LACS), were increased in a PPAR alpha-dependent manner. This increased expression of LACS might enhance the fatty acyl-CoA supply to fatty acid degradation and sulfatide synthesis pathways. In fact, the first and last reactions in the sulfatide synthesis pathway are regulated by PPAR alpha. Therefore, we also measured the expression levels of enzymes involved in sulfatide metabolism and the regulation of cellular sulfatide content. The levels of these enzymes and cellular sulfatide content both increased in a PPAR alpha-dependent manner. These results indicate that PPAR alpha activation plays defensive and compensative roles by reducing cellular toxicity associated with fatty acids and sulfuric acid."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5c01, \u7389\u7476"}], "nameIdentifiers": [{"nameIdentifier": "103698", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "12MH206A_shinsa.pdf", "filesize": [{"value": "105.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 105000.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/18964/files/12MH206A_shinsa.pdf"}, "version_id": "57de7284-0c7f-473a-a8ed-c9b09ef93dc0"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "12MH206A_yoshi.pdf", "filesize": [{"value": "134.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 134800.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/18964/files/12MH206A_yoshi.pdf"}, "version_id": "bff2120f-d43d-4c47-8597-1977c291b8d1"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "12MH206A_ronbun.pdf", "filesize": [{"value": "716.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2016 Tohoku University Medical Press", "licensetype": "license_free", "mimetype": "application/pdf", "size": 716400.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/18964/files/12MH206A_ronbun.pdf"}, "version_id": "9ebffa1c-304b-48ad-a664-be9584559ee7"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Activation of PPAR\u03b1 by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis\uff08\u8102\u80aa\u9178\u84c4\u7a4d\u306b\u3088\u308bPPAR\u03b1\u6d3b\u6027\u5316\u306f\u8102\u80aa\u9178\u5206\u89e3\u3068\u30b9\u30eb\u30d5\u30a1\u30c1\u30c9\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Activation of PPAR\u03b1 by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis\uff08\u8102\u80aa\u9178\u84c4\u7a4d\u306b\u3088\u308bPPAR\u03b1\u6d3b\u6027\u5316\u306f\u8102\u80aa\u9178\u5206\u89e3\u3068\u30b9\u30eb\u30d5\u30a1\u30c1\u30c9\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\uff09"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00019726", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-06-06"}, "publish_date": "2017-06-06", "publish_status": "0", "recid": "18964", "relation": {}, "relation_version_is_last": true, "title": ["Activation of PPAR\u03b1 by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis\uff08\u8102\u80aa\u9178\u84c4\u7a4d\u306b\u3088\u308bPPAR\u03b1\u6d3b\u6027\u5316\u306f\u8102\u80aa\u9178\u5206\u89e3\u3068\u30b9\u30eb\u30d5\u30a1\u30c1\u30c9\u5408\u6210\u3092\u4fc3\u9032\u3059\u308b\uff09"], "weko_shared_id": null}