{"_buckets": {"deposit": "97c4a59a-3389-4b38-97fb-fcfe7d35a842"}, "_deposit": {"id": "18966", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18966"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00018966", "sets": ["849"]}, "author_link": ["103700"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-09-30", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2015-09-30"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。HEPATOLOGY RESEARCH. 47(2):226-233 (2017); doi:10.1111/hepr.12712.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "市川　雪. Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection（血清中のWFA陽性Mac-2結合タンパクはB型肝炎ウイルス慢性感染患者において、肝線維化および肝細胞癌の発症予測に有用な可能性がある）. 信州大学, 2015, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1066号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000394814900011"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27029022"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=27029022", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/hepr.12712"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/hepr.12712", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: Ichikawa, Y., Joshita, S., Umemura, T., Shobugawa, Y., Usami, Y., Shibata, S., Yamazaki, T., Fujimori, N., Komatsu, M., Matsumoto, A., and Tanaka, E. (2017) Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Hepatol Res, 47: 226–233. , which has been published in final form at https://doi.org/10.1111/hepr.12712. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1066号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "hepatitis B virus; hepatocellular carcinoma; liver fibrosis; Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SIMPLE NONINVASIVE INDEX; THERAPY; CIRRHOSIS"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "AimSerum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP) is a reliable, non-invasive marker of liver fibrosis. This study assessed the ability of WFA(+)-M2BP to diagnose liver fibrosis in patients with chronic hepatitis B virus (HBV) infection and evaluated WFA(+)-M2BP as a predictor of hepatocellular carcinoma (HCC) development. MethodsSerum WFA(+)-M2BP values were retrospectively evaluated in 112 treatment-naive patients with HBV-related chronic hepatitis and cirrhosis who had undergone liver biopsy at our hospital. ResultsSerum WFA(+)-M2BP levels were significantly related with liver fibrosis (r=0.3725, P=0.001). Fibrosis stage F2, F3, and F4 had a cut-off index of 0.94, 1.26, and 1.26, respectively. For diagnosing F2 fibrosis, the area under the receiver-operating characteristic curve for WFA(+)-M2BP was 0.713 and comparable with those of other non-invasive fibrosis markers, such as hyaluronic acid, type IV collagen 7S, aspartate aminotransferase-to-platelet ratio index, fibrosis-4 index, serum albumin, and platelet count. Multivariate analysis identified male, WFA(+)-M2BP 0.71, alanine aminotransferase 80IU/L, and platelet count \u003c14.5x10(9)/L as independent risk factors for the development of HCC in patients with HBV infection. ConclusionsSerum WFA(+)-M2BP values appear to be useful for assessing liver fibrosis stage and are independently associated with HCC development in patients with chronic HBV infection."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "市川, 雪"}], "nameIdentifiers": [{"nameIdentifier": "103700", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "10MH037A_shinsa.pdf", "filesize": [{"value": "79.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 79700.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18966/files/10MH037A_shinsa.pdf"}, "version_id": "f4ea2618-947e-41a6-8256-9f986e9153f0"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "10MH037A_yoshi.pdf", "filesize": [{"value": "132.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 132600.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18966/files/10MH037A_yoshi.pdf"}, "version_id": "34dcdadd-7b2b-4841-9580-3f6291c744ab"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "10MH037A_ronbun.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is the peer reviewed version of the following article: Ichikawa, Y., Joshita, S., Umemura, T., Shobugawa, Y., Usami, Y., Shibata, S., Yamazaki, T., Fujimori, N., Komatsu, M., Matsumoto, A., and Tanaka, E. (2017) Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Hepatol Res, 47: 226–233. , which has been published in final form at https://doi.org/10.1111/hepr.12712. 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