{"_buckets": {"deposit": "357b1401-3607-4433-9b30-4e78caa2e68a"}, "_deposit": {"id": "18974", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18974"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00018974", "sets": ["849"]}, "author_link": ["103708"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 10(1):618-624 (2017); doi:.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "金谷　康平. High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma（ADAM10高発現は膠芽腫予後不良因子となる）. 信州大学, 2017, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1074号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000392002100072"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1074号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "ADAM10; Notch1; glioblastoma; immunohistochemistry; prognosis"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CELL-MIGRATION; PROGRESSION; CANCER; DISINTEGRIN; SURVIVAL; TEMOZOLOMIDE; CADHERIN; NOTCH"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "A disintegrin and metalloprotease 10 (ADAM10) is a member of the ADAM family of zinc proteases, which are involved in the shedding of extracellular domains of various cell surface molecule. Several ADAM family members, including ADAM10, have been implicated in cancer growth and progression, however the clinical impact of ADAM10 expression in glioblastoma remains unclear. ADAM10 has an essential role in Notch1 signaling, therefore, we examined the expressions of ADAM10 and Notch1 by immunohistochemistry in 50 patients with IDH1 wild-type glioblastoma. ADAM10 was highly expressed in the tumor specimen of 11 patients but ADAM10 was lowly expressed in 39 patients. No ADAM10 expression was found in normal brain tissue. ADAM10 expression was positively correlated with Notch1 expression (P = 0.002). Low expression of ADAM10 had a tendency to be longer survival in our study. In conclusion, the expression of ADAM10 had a correlation with that of Notch1 in glioblastoma and ADAM10 expression might correlate with tumor growth and be a prognostic factor for patients with glioblastoma."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "金谷, 康平"}], "nameIdentifiers": [{"nameIdentifier": "103708", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "13MH009F_shinsa.pdf", "filesize": [{"value": "93.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 93900.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18974/files/13MH009F_shinsa.pdf"}, "version_id": "60bbf2f1-3d0c-41d0-9218-7051233db04e"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "13MH009F_yoshi.pdf", "filesize": [{"value": "120.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 120900.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18974/files/13MH009F_yoshi.pdf"}, "version_id": "23bd6343-874c-4093-988f-b540c3c24cb9"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "13MH009F_ronbun.pdf", "filesize": [{"value": "644.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 644700.0, "url": {"label": "博士論文の全文", "url": "https://soar-ir.repo.nii.ac.jp/record/18974/files/13MH009F_ronbun.pdf"}, "version_id": "2a4d1d68-f3c6-4503-94f8-4db557759f03"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma（ADAM10高発現は膠芽腫予後不良因子となる）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma（ADAM10高発現は膠芽腫予後不良因子となる）", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00019736", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-06"}, "publish_date": "2017-06-06", "publish_status": "0", "recid": "18974", "relation": {}, "relation_version_is_last": true, "title": ["High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma（ADAM10高発現は膠芽腫予後不良因子となる）"], "weko_shared_id": -1}