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Little is known about the utility of CysC and its association with cardiometabolic risks in young subjects. Methods and results: In a cohort of 454 Japanese junior high school students, the distribution of serum CysC levels and associated variables were analyzed. CysC levels were significantly higher in boys than in girls (0.92 +/- 0.10 mg/L vs. 0.77 +/- 0.08 mg/L, p \u003c 0.001). CysC was significantly correlated with serum creatinine (r = 0.473, p \u003c 0.001), and serum uric acid (SUA) (r = 0.546, p \u003c 0.001). Multivariable regression analysis revealed significant associations between CysC and SUA in all subjects (beta = 0.241, p \u003c 0.001), and in boys and girls separately (beta = 0.264 and 0.240, respectively, both p \u003c 0.001). Importantly, subjects with elevation of both serum CysC and SUA levels had the highest ratio of triglyceride to high-density lipoprotein cholesterol. Conclusions: CysC had significant associations with both creatinine and SUA in Japanese junior high school students. The concomitant elevation of serum CysC and SUA levels was associated with subclinical lipid metabolism dysregulation, and suggested the presence of cardiometabolic risk accumulation. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Importance of cystatin C and uric acid levels in the association of cardiometabolic risk factors in Japanese junior high school students(日本人中学生の心血管代謝危険因子との関連におけるシスタチンCおよび血清尿酸値の重要性)

http://hdl.handle.net/10091/00019738
845b5c9c-2281-4e2f-a9a3-3c603537e4aa
名前 / ファイル ライセンス アクション
12MH021A_shinsa.pdf 内容の要旨 (128.6 kB)
12MH021A_yoshi.pdf 審査結果の要旨 (162.9 kB)
12MH021A_ronbun.pdf 博士論文の全文 (213.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-06-06
タイトル
言語 en
タイトル Importance of cystatin C and uric acid levels in the association of cardiometabolic risk factors in Japanese junior high school students(日本人中学生の心血管代謝危険因子との関連におけるシスタチンCおよび血清尿酸値の重要性)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 原田, 美貴子

× 原田, 美貴子

WEKO 103710

原田, 美貴子

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 原田 美貴子. Importance of cystatin C and uric acid levels in the association of cardiometabolic risk factors in Japanese junior high school students(日本人中学生の心血管代謝危険因子との関連におけるシスタチンCおよび血清尿酸値の重要性). 信州大学, 2016, 博士論文.
書誌情報
発行日 2016-03-31
学位授与番号
学位授与番号 13601甲第1076号
学位授与年月日
学位授与年月日 2016-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1076号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。JOURNAL OF CARDIOLOGY. 69(1):222-227 (2017); doi:10.1016/j.jjcc.2016.03.013.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=27138369
関連名称
関連名称 27138369
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jjcc.2016.03.013
関連名称
関連名称 10.1016/j.jjcc.2016.03.013
権利
権利情報 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394195800034
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