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Serum lipopolysaccharide (LPS)-binding protein (LBP) and anti-endotoxin core immunoglobulin G (EndoCab IgG) antibody concentrations at the time of liver biopsy were measured using the enzyme-linked immunosorbent assays to examine for relationships between biomarker levels and histological scores. RESULTS Serum LBP concentration was significantly increased in nonalcoholic steatohepatitis (NASH) patients as compared with nonalcoholic fatty liver (NAFL) subjects and was correlated with steatosis (r = 0.38, P \u003c 0.0001) and ballooning scores (r = 0.23, P = 0.01), but not with the severity of lobular inflammation or fibrosis. Multivariate linear regression analysis revealed that LBP was associated with steatosis score and circulating C-reactive protein, aspartate aminotransferase, and fibrinogen levels. Serum EndoCab IgG concentration was comparable between NASH and NAFL patients. No meaningful correlations were detected between EndoCab IgG and histological findings. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Association between endotoxemia and histological features of nonalcoholic fatty liver disease(非アルコール性脂肪性肝疾患における組織像とエンドトキシン血症との関連)

http://hdl.handle.net/10091/00019749
fa855aae-8c7b-43f5-b43e-22f2eb393152
名前 / ファイル ライセンス アクション
13MH213G_shinsa.pdf 内容の要旨 (117.1 kB)
13MH213G_yoshi.pdf 審査結果の要旨 (169.6 kB)
13MH213G_ronbun.pdf 博士論文の全文 (641.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-06-06
タイトル
言語 en
タイトル Association between endotoxemia and histological features of nonalcoholic fatty liver disease(非アルコール性脂肪性肝疾患における組織像とエンドトキシン血症との関連)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 北畠, 央之

× 北畠, 央之

WEKO 103721

北畠, 央之

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 北畠 央之. Association between endotoxemia and histological features of nonalcoholic fatty liver disease(非アルコール性脂肪性肝疾患における組織像とエンドトキシン血症との関連). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-03-31
学位授与番号
学位授与番号 13601甲第1089号
学位授与年月日
学位授与年月日 2017-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1089号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。WORLD JOURNAL OF GASTROENTEROLOGY. 23(4):712-722 (2017); doi:10.3748/wjg.v23.i4.712.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=28216979
関連名称
関連名称 28216979
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3748/wjg.v23.i4.712
関連名称
関連名称 10.3748/wjg.v23.i4.712
権利
権利情報 ©The Authors 2017. Published by Baishideng Publishing Group Inc. All rights reserved. Articles published by this open-access journal are distributed under the terms of the Creative Commons Attribution-Noncommercial (CC BY-NC 4.0) License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000392232700017
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