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Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明). 信州大学, 2016, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1092号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000398140800001"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28216546"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/28216546/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1620/tjem.241.175"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1620/tjem.241.175", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2016 Tohoku University Medical Press"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1092号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Bach2; eosinophilia; eosinophils; helper T cell type 2; innate lymphoid cells"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "INNATE LYMPHOID-CELLS; ALVEOLAR MACROPHAGE FUNCTION; SURFACTANT HOMEOSTASIS; REPRESSOR BACH2; BONE-MARROW; IFN-GAMMA; IDENTIFICATION; TRANSCRIPTION; INTERLEUKIN-5; MICE"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Bach2 is a transcription factor which represses its target genes and plays important roles in the differentiation of B and T lymphoid cells. Bach2-deficient (KO) mice develop severe pulmonary alveolar proteinosis, which is associated with increased numbers of granulocytes and T cells. Bach2 is essential for the regulation of T cells, but its role in the regulation of granulocytes is not clear. Here, we observed increased numbers of eosinophils but not neutrophils in the bone marrow, spleen, peripheral blood, and bronchoalveolar lavage fluids of Bach2 KO mice compared with those of wild-type (WT) mice. Upon co-transplantation of the bone marrow cells from CD45.2 Bach2 KO and CD45.1/CD45.2 double-positive WT mice to irradiated WT CD45.1/CD45.2 mice, the reconstituted numbers of eosinophils were similar between Bach2 KO and WT cells. These results showed that the deficiency of Bach2 in eosinophils did not directly drive the differentiation of eosinophils. To investigate the effect of Bach2 KO CD4(+) T cells upon eosinophils, we analyzed Rag2/Bach2-double deficient (dKO) mice which lack lymphocytes including CD4(+) T cells. Rag2/Bach2 dKO mice did not show any increase in the numbers of eosinophils. Importantly, Bach2 KO mice showed an increase of interleukin-5 (11-5) in the sera compared with WT mice. These results suggest that up-regulated functions of CD4(+) T cells including secretion of 11-5 resulted in proliferation and/or migration to peripheral tissues of eosinophils in Bach2 KO mice. We propose that Bach2 controls homeostasis of eosinophils via restricting the production of 11-5 in CD4(+) T cells."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "佐藤, 勇樹", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "103724", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "12MH023H_shinsa.pdf", "filesize": [{"value": "93.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 93200.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18990/files/12MH023H_shinsa.pdf"}, "version_id": "a8d4f873-f44b-4a6e-8f92-08a86ba8f3de"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "12MH023H_yoshi.pdf", "filesize": [{"value": "159.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 159700.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18990/files/12MH023H_yoshi.pdf"}, "version_id": "4303075c-1b35-4855-a9fe-2f4d470abe8c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "12MH023H_ronbun.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2016 Tohoku University Medical Press", "licensetype": "license_note", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/18990/files/12MH023H_ronbun.pdf"}, "version_id": "124228cf-d58e-467f-9ea7-938ae8e249f1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明)", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00019752", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-06"}, "publish_date": "2017-06-06", "publish_status": "0", "recid": "18990", "relation": {}, "relation_version_is_last": true, "title": ["Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明)"], "weko_shared_id": -1}
Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明)
http://hdl.handle.net/10091/00019752
http://hdl.handle.net/10091/00019752a41bafb9-9f57-41b0-8f59-9a7dc8341f71
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内容の要旨 (93.2 kB)
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審査結果の要旨 (159.7 kB)
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博士論文の全文 (2.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-06-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
佐藤, 勇樹
× 佐藤, 勇樹 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 佐藤 勇樹. Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells(転写因子Bach2によるヘルパーT細胞を介した好酸球増多機構の解明). 信州大学, 2016, 博士論文. | |||||
書誌情報 |
発行日 2016-03-31 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第1092号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1092号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE. 241(3):175-182 (2017); doi:10.1620/tjem.241.175. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/28216546/ | |||||
関連名称 | 28216546 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1620/tjem.241.175 | |||||
関連名称 | 10.1620/tjem.241.175 | |||||
権利 | ||||||
権利情報 | © 2016 Tohoku University Medical Press | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000398140800001 |