{"_buckets": {"deposit": "e2bc86a4-8629-4a72-a0f5-8b3cade88136"}, "_deposit": {"id": "18998", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18998"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00018998", "sets": ["849"]}, "author_link": ["103732"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-09-28", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2016-09-28"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。ANESTHESIOLOGY. 125(1):204-218 (2016); doi:10.1097/ALN.0000000000001152.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "布施谷　仁志. Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice（QX-314全身投与は、マウスにおいてはTransient Receptor Potential Vanilloid Subfamily 1を発現している1次知覚神経を選択的に抑制することによって骨がん痛を減弱させる）. 信州大学, 2016, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601乙第1198号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000384919100031"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "27176211"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=27176211", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1097/ALN.0000000000001152"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1097/ALN.0000000000001152", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is a non-final version of an article published in final form in (Anesthesiology. 125(1):204–218, JUL 2016). http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2524646"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "乙第1198号"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ROOT GANGLION NEURONS; LASTING LOCAL-ANESTHESIA; NERVE-FIBERS; DISTINCT SUBPOPULATIONS; TRPV1 ANTAGONIST; SKELETAL PAIN; ION CHANNELS; MURINE MODEL; SPINAL-CORD; LIDOCAINE"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background: The aim of this study was to determine whether systemic administration of QX-314 reduces bone cancer pain through selective inhibition of transient receptor potential vanilloid subfamily 1 (TRPV1)-expressing afferents. Methods: A mouse model of bone cancer pain was used. The authors examined the effects of bolus (0.01 to 3 mg/kg, n = 6 to 10) and continuous (5 mg kg(-1) h(-1), n = 5) administration of QX-314 on both bone cancer pain-related behaviors and phosphorylated cyclic adenosine monophosphate response element-binding protein expression in dorsal root ganglion neurons (n = 3 or 6) and the effects of ablation of TRPV1-expressing afferents on bone cancer pain-related behaviors (n = 10). Results: The numbers of flinches indicative of ongoing pain in QX-314-treated mice were smaller than those in vehicle-treated mice at 10 min (3 mg/kg, 4 +/- 3; 1 mg/kg, 5 +/- 3 vs. 12 +/- 3; P \u003c 0.001; n = 8 to 9), 24 h (3 +/- 2 vs. 13 +/- 3, P \u003c 0.001), and 48 h (4 +/- 1 vs. 12 +/- 2, P \u003c 0.001; n = 5 in each group) after QX-314 administration, but impaired limb use, weight-bearing including that examined by the CatWalk system, and rotarod performance indicative of movement-evoked pain were comparable. QX-314 selectively inhibited the increase in phosphorylated cyclic adenosine monophosphate response elementbinding protein expression in TRPV1-positive, but not in TRPV1-negative, dorsal root ganglion neurons compared to that in the case of vehicle administration (32.2 +/- 3.0% vs. 52.6 +/- 5.9%, P \u003c 0.001; n = 6 in each group). Ablation of TRPV1expressing afferents mimicked the effects of QX-314. Conclusion: This study showed that systemic administration of QX-314 in mice inhibits some behavioral aspects of bone cancer pain through selective inhibition of TRPV1-expressing afferents without coadministration of TRPV1 agonists."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "布施谷, 仁志"}], "nameIdentifiers": [{"nameIdentifier": "103732", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "16MR0005_shinsa.pdf", "filesize": [{"value": "130.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 130699.99999999999, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18998/files/16MR0005_shinsa.pdf"}, "version_id": "97bf3a7c-461f-4de3-94d9-fcaa0b7b9143"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "16MR0005_yoshi.pdf", "filesize": [{"value": "116.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 116900.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/18998/files/16MR0005_yoshi.pdf"}, "version_id": "75dbdd0f-208d-4614-ab3a-62130035ef9b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-07-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "16MR0005_ronbun.pdf", "filesize": [{"value": "3.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is a non-final version of an article published in final form in (Anesthesiology. 125(1):204–218, JUL 2016). http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2524646", "licensetype": "license_note", "mimetype": "application/pdf", "size": 3600000.0, "url": {"label": "博士論文の全文", "url": "https://soar-ir.repo.nii.ac.jp/record/18998/files/16MR0005_ronbun.pdf"}, "version_id": "0dd8c4ea-9e2d-445b-a1f3-ccee0074170a"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice（QX-314全身投与は、マウスにおいてはTransient Receptor Potential Vanilloid Subfamily 1を発現している1次知覚神経を選択的に抑制することによって骨がん痛を減弱させる）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice（QX-314全身投与は、マウスにおいてはTransient Receptor Potential Vanilloid Subfamily 1を発現している1次知覚神経を選択的に抑制することによって骨がん痛を減弱させる）", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00019760", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-06"}, "publish_date": "2017-06-06", "publish_status": "0", "recid": "18998", "relation": {}, "relation_version_is_last": true, "title": ["Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1-expressing Primary Afferents in Mice（QX-314全身投与は、マウスにおいてはTransient Receptor Potential Vanilloid Subfamily 1を発現している1次知覚神経を選択的に抑制することによって骨がん痛を減弱させる）"], "weko_shared_id": -1}