{"_buckets": {"deposit": "2a70aed0-5e56-4119-bef4-3520a543fc3b"}, "_deposit": {"id": "19007", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19007"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00019007", "sets": ["849"]}, "author_link": ["103748"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。The American Journal of Pathology. 187(5):99-1015 (2017); doi:10.1016/j.ajpath.2017.01.014.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "今井　章. Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy（アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する）. 信州大学, 2017, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1086号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000400229600007"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "28322199"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=28322199", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.ajpath.2017.01.014"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.ajpath.2017.01.014", "subitem_relation_type_select": "DOI"}}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1086号"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "RETINAL BARRIER BREAKDOWN; DIABETIC MACULAR EDEMA; MOUSE MODEL; PLASMA ADRENOMEDULLIN; ELEVATED ADRENOMEDULLIN; PIGMENT EPITHELIUM; IN-VITRO; KAPPA-B; ANGIOGENESIS; VEGF"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Diabetic macular edema (DME) is caused by blood-retinal barrier breakdown associated with retinal vascular hyperpermeability and inflammation, and it is the major cause of visual dysfunction in diabetic retinopathy. Adrenomedullin (ADM) is an endogenous peptide first identified as a strong vasodilator. ADM is expressed in the eyes and is up-regulated in various eye diseases, although the pathophysiological significance is largely unknown. We investigated the effect of ADM on DME. In Kimba mice, which overexpress human vascular endothelial growth factor in their retinas, the capillary dropout, vascular leakage, and vascular fragility characteristic of diabetic retinopathy were observed. Intravitreal or systemic administration of ADM to Kimba mice ameliorated both the capillary dropout and vascular leakage. Evaluation of the transendothelial electrical resistance and fluorescein isothiocyanate-dextran permeability of an endothelial cell monolayer using TR-iBRB retinal capillary endothelial cells revealed that vascular endothelial growth factor enhanced vascular permeability but that co-administration of ADM suppressed the effect, in part by enhancing tight junction formation between endothelial cells. In addition, a comprehensive PCR array analysis showed that ADM administration suppressed various molecules related to inflammation and NF-kappa B signaling within retinas. From these results, we suggest that by exerting inhibitory effects on retinal inflammation, vascular permeability, and blood-retinal barrier breakdown, ADM could serve as a novel therapeutic agent for the treatment of DME."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "今井, 章"}], "nameIdentifiers": [{"nameIdentifier": "103748", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "13MH201C_shinsa.pdf", "filesize": [{"value": "128.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 128500.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19007/files/13MH201C_shinsa.pdf"}, "version_id": "3890a127-f488-4d47-82f7-aec7c80e8969"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "13MH201C_yoshi.pdf", "filesize": [{"value": "127.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 127100.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/19007/files/13MH201C_yoshi.pdf"}, "version_id": "5b6b2702-3cb5-40b9-a705-25c0db93d8c1"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-03-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "13MH201C_ronbun.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_note", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "博士論文の全文", "url": "https://soar-ir.repo.nii.ac.jp/record/19007/files/13MH201C_ronbun.pdf"}, "version_id": "4cc89664-f1ac-4e5f-b5c1-5ab4f4819fad"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy（アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy（アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する）", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00019769", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-06-14"}, "publish_date": "2017-06-14", "publish_status": "0", "recid": "19007", "relation": {}, "relation_version_is_last": true, "title": ["Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy（アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する）"], "weko_shared_id": -1}