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Adrenomedullin (ADM) is an endogenous peptide first identified as a strong vasodilator. ADM is expressed in the eyes and is up-regulated in various eye diseases, although the pathophysiological significance is largely unknown. We investigated the effect of ADM on DME. In Kimba mice, which overexpress human vascular endothelial growth factor in their retinas, the capillary dropout, vascular leakage, and vascular fragility characteristic of diabetic retinopathy were observed. Intravitreal or systemic administration of ADM to Kimba mice ameliorated both the capillary dropout and vascular leakage. Evaluation of the transendothelial electrical resistance and fluorescein isothiocyanate-dextran permeability of an endothelial cell monolayer using TR-iBRB retinal capillary endothelial cells revealed that vascular endothelial growth factor enhanced vascular permeability but that co-administration of ADM suppressed the effect, in part by enhancing tight junction formation between endothelial cells. In addition, a comprehensive PCR array analysis showed that ADM administration suppressed various molecules related to inflammation and NF-kappa B signaling within retinas. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy(アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する)

http://hdl.handle.net/10091/00019769
http://hdl.handle.net/10091/00019769
ea95c4b0-8b9a-4d78-b403-9f3819e6f283
名前 / ファイル ライセンス アクション
13MH201C_shinsa.pdf 内容の要旨 (128.5 kB)
13MH201C_yoshi.pdf 審査結果の要旨 (127.1 kB)
13MH201C_ronbun.pdf 博士論文の全文 (1.9 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2017-06-14
タイトル
言語 en
タイトル Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy(アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 今井, 章

× 今井, 章

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今井, 章

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 今井 章. Adrenomedullin suppresses VEGF-induced vascular hyperpermeability and inflammation in retinopathy(アドレノメデュリンは、網膜症において、VEGFにより誘発される血管透過性亢進と炎症を抑制する). 信州大学, 2017, 博士論文.
書誌情報
発行日 2017-03-31
学位授与番号
学位授与番号 13601甲第1086号
学位授与年月日
学位授与年月日 2017-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1086号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。The American Journal of Pathology. 187(5):99-1015 (2017); doi:10.1016/j.ajpath.2017.01.014.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=28322199
関連名称 28322199
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ajpath.2017.01.014
関連名称 10.1016/j.ajpath.2017.01.014
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000400229600007
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