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Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
http://hdl.handle.net/10091/00019820
362f969e-5314-4ca9-96f5-9505e751270a
名前 / ファイル | ライセンス | Actions | |
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© 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-20 | |||||
タイトル | ||||||
タイトル | Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Morita, Susumu
× Morita, Susumu× Joshita, Satoru× Umemura, Takeji× Katsuyama, Yoshihiko× Kimura, Takefumi× Komatsu, Michiharu× Matsumoto, Akihiro× Yoshizawa, Kaname× Kamijo, Atsushi× Yamamura, Nobuyoshi× Tanaka, Eiji× Ota, Masao |
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信州大学研究者総覧へのリンク | ||||||
Joshita, Satoru | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Umemura, Takeji | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Kimura, Takefumi | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.uNymWUkh.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Matsumoto, Akihiro | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCPUym.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Tanaka, Eiji | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Ota, Masao | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | ||||||
出版者 | ||||||
出版者 | ELSEVIER SCIENCE INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | HUMAN IMMUNOLOGY. 74(2):219-222 (2013) | |||||
書誌情報 |
HUMAN IMMUNOLOGY 巻 74, 号 2, p. 219-222, 発行日 2013-02 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure. Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria. Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal hepatocytes in liver tissues of PBC. To assess the potential contribution of TLR4 SNPs to the development of this disease, we genotyped five SNPs in TLR4 in 261 PBC patients and 359 controls using a TaqMan assay. No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0198-8859 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00214087 | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=23142582 | |||||
関連名称 | ||||||
関連名称 | 23142582 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.1016/j.humimm.2012.10.022 | |||||
関連名称 | ||||||
関連名称 | 10.1016/j.humimm.2012.10.022 | |||||
権利 | ||||||
権利情報 | © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
値 | author | |||||
WoS | ||||||
Web of Science | ||||||
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000317874000014 |