| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-09-20 |
| タイトル |
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|
タイトル |
Human Leukocyte Antigen Class II Haplotypes Affect Clinical Characteristics and Progression of Type 1 Autoimmune Hepatitis in Japan |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0100565 |
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関連名称 |
10.1371/journal.pone.0100565 |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Umemura, Takeji
Katsuyama, Yoshihiko
Yoshizawa, Kaname
Kimura, Takefumi
Joshita, Satoru
Komatsu, Michiharu
Matsumoto, Akihiro
Tanaka, Eiji
Ota, Masao
|
| 信州大学研究者総覧へのリンク |
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氏名 |
Umemura, Takeji |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Kimura, Takefumi |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uNymWUkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Joshita, Satoru |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Matsumoto, Akihiro |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCPUym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Tanaka, Eiji |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Ota, Masao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html |
| 出版者 |
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出版者 |
PUBLIC LIBRARY SCIENCE |
| 引用 |
|
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内容記述 |
PLOS ONE. 9(6):e100565 (2014) |
| 書誌情報 |
PLOS ONE
巻 9,
号 6,
p. e100565,
発行日 2014-06-16
|
| 抄録 |
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内容記述 |
Although we earlier demonstrated that the human leukocyte antigen (HLA) DRB1*04:05 allele was associated with susceptibility to autoimmune hepatitis (AIH) in Japan, the precise relationship of HLA haplotype and the role of amino acid alignment with disease susceptibility and progression has not been fully clarified. We reinvestigated HLA class I A, B, and C and HLA class II DRB1, DQB1, and DPB1 alleles and haplotypes in a larger new cohort of 156 Japanese patients with type 1 AIH and compared them with the published data of 210 healthy subjects. The DRB1*04: 05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2x10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006). No associations with HLA-DPB1 alleles were found. The HLA A*24:02 and C*01:02 alleles were associated with disease susceptibility (corrected P = 0.0053 and 0.036, respectively), but this likely constituents of a long ranged haplotype including DRB1*04:05-DQB1*04:01 haplotype. Conversely, the DRB1*15:01-DQB1*06:02 haplotype was associated with protection from both disease onset (5% vs. 13%, P = 0.00057; OR = 0.38) and the development of hepatocellular carcinoma (25% vs. 5%, P = 0.017; OR = 6.81). The frequency of the DRB1*08:03-DQB1*06:01 haplotype was significantly higher in patients who developed hepatic failure (22% vs. 6%, P = 0.034; OR = 4.38). In conclusion, this study established the role of HLA haplotypes in determining AIH susceptibility and progression in the Japanese population. Additional sequencing of the entire HLA region is required to more precisely identify the genetic components of AIH. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1932-6203 |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/24956105 |
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関連名称 |
24956105 |
| 権利 |
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権利情報 |
© 2014 Umemura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000338917900068 |
Human_Leukocyte_Antigen_Class_II_Haplotypes_Affect_Clinical_Characteristics.pdf (256.5 kB)
